Abdulkhaleq Layth Abdulmajeed, Assi Mohammed Abdulrazzaq, Noor Mohd Hezmee Mohd, Abdullah Rasedee, Saad Mohd Zamri, Taufiq-Yap Yun Hin
Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Department of Pathology and Poultry Diseases, Faculty of Veterinary Medicine, Baghdad University, Baghdad, Iraq.
Vet World. 2017 Aug;10(8):869-872. doi: 10.14202/vetworld.2017.869-872. Epub 2017 Aug 6.
Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while is anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which is diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on human while understanding the potential mechanisms of these aforementioned effects.
表儿茶素是一种存在于绿茶中的天然黄酮类化合物。据报道，它具有巨大的抗氧化作用，这有助于其对多种疾病的治疗效果。在本综述中，我们讨论了它在两种最重要的人类疾病——糖尿病和癌症的治疗中的作用。已证明食用表儿茶素可降低糖尿病患者的血糖水平，而其抗癌作用归因于其抗氧化特性、抗血管生成作用以及对癌细胞的直接细胞毒性。尽管表儿茶素的确切作用机制仍在探索中，但毫无疑问它是一个有前景的替代候选物。本综述的意义在于强调使用天然产物（在这种情况下是表儿茶素）作为治疗两种潜在致命疾病——糖尿病和癌症的替代方法的重要性。本综述的目的是让科学界了解表儿茶素在改善糖尿病和癌症对人类的影响方面的作用，同时了解上述影响的潜在机制。
