Pepin J, Milord F, Guern C, Schechter P J
University of Sherbrooke, Canada.
Lancet. 1987 Dec 19;2(8573):1431-3. doi: 10.1016/s0140-6736(87)91131-7.
26 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel improvement in central nervous system status. Side-effects, including diarrhoea, anaemia, and hair loss, were common but tolerable and reversible. 5 patients died during or shortly after treatment. None of the 21 patients who completed therapy has had a relapse during the 6-30 month follow-up.
26名患有抗砷性布氏冈比亚锥虫病的患者接受了静脉注射后口服的鸟氨酸脱羧酶抑制剂二氟甲基鸟氨酸（依氟鸟氨酸）治疗。脑脊液中的锥虫迅速消失，脑脊液淋巴细胞增多症逐渐减轻，中枢神经系统状况同步改善。包括腹泻、贫血和脱发在内的副作用很常见，但可耐受且可逆。5名患者在治疗期间或治疗后不久死亡。在6至30个月的随访期间，完成治疗的21名患者均未复发。
