Division of Translational Neuroscience, Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
J Neural Transm (Vienna). 2017 Dec;124(12):1635-1640. doi: 10.1007/s00702-017-1790-z. Epub 2017 Sep 18.
Behavioural inflexibility and associated atypical learning behaviours are common clinical manifestations of the autism spectrum disorder (ASD) phenotype. Despite advances in our understanding of ASD, little research has been devoted to experimental interventions that might help to circumvent behavioural inflexibility in ASD. The current paper suggests that motivational locomotion in the form of wheel running can reduce behavioural inflexibility and learning impairments in an ASD rat model, and discusses how the strategy of reward-coupled locomotor activity may lead to clinical interventions for children with ASD.
行为灵活性差和相关的非典型学习行为是自闭症谱系障碍（ASD）表型的常见临床特征。尽管我们对 ASD 的理解有了进步，但很少有研究致力于可能有助于规避 ASD 中行为灵活性差的实验干预措施。本文提出，以轮式跑步形式的动机性运动可以减少 ASD 大鼠模型中的行为灵活性和学习障碍，并讨论了奖励耦合运动活动策略如何为 ASD 儿童带来临床干预措施。
