Department of Neurobiology/Brain Research, Weizmann Institute of Science, Rehovot, Israel.
Jerusalem Center for Mental Health, Hebrew University, Jerusalem, Israel.
Nat Neurosci. 2015 Nov;18(11):1574-6. doi: 10.1038/nn.4129. Epub 2015 Oct 5.
Inflexible behavior is a core characteristic of autism spectrum disorder (ASD), but its underlying cause is unknown. Using a perceptual learning protocol, we observed initially efficient learning in ASD that was followed by anomalously poor learning when the location of the target was changed (over-specificity). Reducing stimulus repetition eliminated over-specificity. Our results indicate that inflexible behavior may be evident ubiquitously in ASD, even in sensory learning, but can be circumvented by specifically designed stimulation protocols.
刻板行为是自闭症谱系障碍（ASD）的核心特征，但其根本原因尚不清楚。使用感知学习协议，我们观察到 ASD 患者最初的学习效率很高，但当目标位置改变时（过度特异性），学习效率异常低下。减少刺激重复可以消除过度特异性。我们的结果表明，刻板行为在 ASD 中可能普遍存在，即使在感觉学习中也是如此，但可以通过专门设计的刺激方案来规避。
