Thurber Mary Irene, Gjeltema Jenessa, Sheley Matthew, Wack Ray F
J Zoo Wildl Med. 2017 Sep;48(3):929-932. doi: 10.1638/2016-0271.1.
A 10-year-old male castrated red kangaroo (Macropus rufus) presented with mandibular swelling. Examination findings included pitting edema with no dental disease evident on examination or radiographs. The results of blood work were moderate azotemia, hypoalbuminemia, and severely elevated urine protein:creatinine ratio (9.9). Radiographs showed an interstitial pattern of the caudal right lung, and an abdominal ultrasound demonstrated scant effusion. Symptomatic and empirical therapy with antibiotics, anti-inflammatory drugs, and an angiotensin-converting enzyme (ACE) inhibitor did not resolve clinical signs. Due to poor prognosis and declining quality of life, euthanasia was elected. Necropsy revealed chronic granulomatous pneumonia of the caudal right lung lobe with intralesional Cryptococcus, identified as C. neoformans var. grubii by DNA sequencing. Severe bilateral glomerular and tubulointerstitial amyloidosis induced protein-losing nephropathy, leading to tri-cavitary effusion, subcutaneous edema, and cachexia. The authors speculate that renal amyloidosis was associated with chronic cryptococcal pneumonia in this red kangaroo.
一只10岁的雄性去势红袋鼠（赤大袋鼠）出现下颌肿胀。检查结果包括凹陷性水肿，检查或X光片上均未发现明显的牙齿疾病。血液检查结果为中度氮质血症、低白蛋白血症，尿蛋白：肌酐比值严重升高（9.9）。X光片显示右肺尾叶呈间质模式，腹部超声显示有少量积液。使用抗生素、抗炎药和血管紧张素转换酶（ACE）抑制剂进行对症和经验性治疗未能消除临床症状。由于预后不良和生活质量下降，选择了安乐死。尸检发现右肺尾叶慢性肉芽肿性肺炎，病灶内有新型隐球菌，通过DNA测序鉴定为新型隐球菌格鲁比变种。严重的双侧肾小球和肾小管间质淀粉样变性导致蛋白尿性肾病，进而导致三腔积液、皮下水肿和恶病质。作者推测，这只红袋鼠的肾淀粉样变性与慢性隐球菌肺炎有关。
