Sakassegawa-Naves Fernando Eiji, Ricci Helena Maria Moraes, Moscovici Bernardo Kaplan, Miyamoto Daniela Akemi, Chiacchio Brenda Biagio, Holzchuh Ricardo, Santo Ruth Muyuki, Hida Richard Yudi
a Department of Ophthalmology , Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil.
b Department of Ophthalmology , Santa Casa de Misericórdia de São Paulo , São Paulo , Brazil.
Curr Eye Res. 2017 Nov;42(11):1440-1444. doi: 10.1080/02713683.2017.1339805. Epub 2017 Sep 18.
This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.
Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14 days and 28 days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline.
We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group.
This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.
本前瞻性、随机、双盲干预性病例系列旨在评估0.03%他克莫司软膏作为难治性睑缘炎新治疗方法的短期疗效。
将40只眼（20例患者）对先前治疗无效的难治性睑缘炎患者随机分组。18只眼（9例患者）每日两次使用0.03%他克莫司软膏治疗，20只眼（10例患者）使用安慰剂软膏治疗。在治疗后14天和28天通过问卷调查和裂隙灯检查对患者进行评估，并将睑缘炎的症状和体征与基线观察结果进行比较。
我们观察到研究组在睑板腺分泌、结膜充血、下睑毛细血管扩张、孟加拉玫瑰红和荧光素评分的结果测量上存在统计学差异。至于症状评分，我们观察到他克莫司组在瘙痒和干眼感觉的症状评分上存在统计学差异。
本研究表明，局部应用0.03%他克莫司软膏可改善难治性睑缘炎患者的一些症状和部分眼表状况。
