Department of Mechanical & Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Department of Mechanical & Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
J Colloid Interface Sci. 2018 Jan 1;509:414-421. doi: 10.1016/j.jcis.2017.09.015. Epub 2017 Sep 7.
A novel highly controllable process of Carbon Encapsulated Magnetic Nanoparticles (CEMNs) synthesis in arc discharge plasma has been developed. In this work, both the size distribution and the purity of the CEMNs have been made more controllable by adding an external magnetic field. It is shown that with the increase of the external magnetic field, the CEMNs get a better separation from the carbon impurities and the size distribution become narrower. This conclusion is valid for Fe, Ni and Fe+Ni CEMNs synthesis. In order to assess biomedical potential of these CEMNs, the cytotoxicity has also been measured for the human breast adenocarcinoma cell line MDA-MB-231. It was concluded that the CEMNs with the concentration in cell of about 0.0001-0.01ug/ml are not toxic.
一种新型的在电弧放电等离子体中可控合成碳包覆磁性纳米颗粒（CEMNs）的方法已经被开发出来。在这项工作中，通过施加外部磁场，使 CEMNs 的尺寸分布和纯度更加可控。结果表明，随着外部磁场的增加，CEMNs 与碳杂质更好地分离，尺寸分布变得更窄。这一结论对于 Fe、Ni 和 Fe+Ni CEMNs 的合成都是有效的。为了评估这些 CEMNs 的生物医学潜力，还测量了它们对人乳腺癌细胞系 MDA-MB-231 的细胞毒性。结果表明，当 CEMNs 的浓度在细胞中约为 0.0001-0.01ug/ml 时，它们没有毒性。
