Center for Micro-BioRobotics, Istituto Italiano di Tecnologia, 56025 Pontedera, Italy.
Departamento de Química Física-CINBIO, Universidade de Vigo, Vigo 36310, Spain.
J Colloid Interface Sci. 2017 Sep 15;502:201-209. doi: 10.1016/j.jcis.2017.04.089. Epub 2017 Apr 28.
We report here on the fabrication of a new example of nano-object that combines magnetic and plasmonic properties. The strategy is based on the electrostatic assembly of negatively charged gold nanorods (NIR-resonant) on positively charged silica-coated iron oxide nanoparticles. Silica coating of magnetic nanoparticles prevented iron oxide nanoparticles irreversible aggregation in water environment. Finally the stability of the nanocomposite in biological medium has been improved through a protein coating (BSA, bovine serum albumin). Morphological, optical and magnetic properties of the hybrid nanomaterials have been evaluated as well as its ability to be manipulated by an external magnetic field. Furthermore, temperature characterization upon NIR laser excitation has been performed in order to assess nanocomposite capability of increasing local environmental temperature. This nanomaterial could be used as a smart tool for photothermal treatment of cancerous lesions in order to maximize precision and efficacy of tissue heating upon laser stimulation by magnetically accumulating nanoparticles nearby the cancerous lesion, avoiding dispersion of the nanomaterial.
我们在此报告一种新的纳米物体的制造实例，该实例结合了磁性和等离子体特性。该策略基于带负电荷的金纳米棒（NIR 共振）在带正电荷的二氧化硅涂层氧化铁纳米颗粒上的静电组装。磁性纳米颗粒的二氧化硅涂层防止了氧化铁纳米颗粒在水环境中的不可逆聚集。最后，通过蛋白质涂层（BSA，牛血清白蛋白）提高了纳米复合材料在生物介质中的稳定性。对混合纳米材料的形貌、光学和磁性特性以及通过外部磁场进行操纵的能力进行了评估。此外，还进行了 NIR 激光激发下的温度特性表征，以评估纳米复合材料增加局部环境温度的能力。这种纳米材料可作为光热治疗癌症病变的智能工具，通过在癌症病变附近磁性聚集纳米颗粒来最大限度地提高组织加热的精度和效果，避免纳米材料的分散。
