Rajcáni J, Reefschläger J
Institute of Virology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Acta Virol. 1987 Aug;31(4):329-39.
Four nucleoside analogues--acyclovir [9-(2-hydroxyethoxymethyl)guanine], bromovinyldeoxyuridine [(E)-5-(2-bromovinyl)-2-deoxyuridine], vinylarauracil 5-vinyl-1-beta-D-arabinofuranosyluracil and bromovinylarauracil [(E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil]--were compared in the therapy of acute keratitis induced in the rabbit cornea by inoculation of the KUPKA strain of herpes simplex virus type 1 (HSV-1). In comparison to placebo-treated animals, the drugs reduced the mean plaque counts in conjunctival swabs as follows: acyclovir to 0.16-1.73%, bromovinyldeoxyuridine to 0.02-0.25%, vinylarauracil to 0.55-5.96% and bromovinylarauracil to 0.12-3.39% of control values. Latency was established to a most limited extent in 1 or 2 out of 5 rabbits treated with vinylarauracil or bromovinylarauracil, respectively. One or 6 out of 84 or 98 explanted ganglion fragments (1.3 or 6%) were positive for HSV-1 as compared to 72 fragments out of 173 (43%) from placebo-treated rabbits. Acyclovir and bromovinyldeoxyuridine completely prevented latency.
将四种核苷类似物——阿昔洛韦[9-(2-羟乙氧甲基)鸟嘌呤]、溴乙烯脱氧尿苷[(E)-5-(2-溴乙烯基)-2-脱氧尿苷]、乙烯阿糖胞苷（5-乙烯基-1-β-D-阿拉伯呋喃糖基尿嘧啶）和溴乙烯阿糖胞苷[(E)-5-(2-溴乙烯基)-1-β-D-阿拉伯呋喃糖基尿嘧啶]——用于治疗通过接种1型单纯疱疹病毒（HSV-1）库普卡株在兔角膜诱发的急性角膜炎，并进行了比较。与接受安慰剂治疗的动物相比，这些药物使结膜拭子中的平均噬斑计数降低如下：阿昔洛韦降至对照值的0.16 - 1.73%，溴乙烯脱氧尿苷降至0.02 - 0.25%，乙烯阿糖胞苷降至0.55 - 5.96%，溴乙烯阿糖胞苷降至0.12 - 3.39%。在用乙烯阿糖胞苷或溴乙烯阿糖胞苷治疗的5只兔子中，分别只有1只或2只兔子在最有限的程度上建立了潜伏感染。与接受安慰剂治疗的兔子的173个神经节片段中有72个（43%）HSV-1呈阳性相比，84个或98个移植的神经节片段中有1个或6个（1.3%或6%）HSV-1呈阳性。阿昔洛韦和溴乙烯脱氧尿苷完全预防了潜伏感染。
