抑制铜绿假单胞菌 MvfR 群体感应系统的药理学干预会干扰生物膜的形成，并增强抗生素介导的生物膜破坏。
Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption.
机构信息
Departments of Surgery and Microbiology and Immunobiology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA, and Shriners Hospitals for Children Boston, Boston, Massachusetts, USA
出版信息
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01362-17. Print 2017 Dec.
Abstract
biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of antibiofilm agents may hold great promise. We show that pharmacological inhibition of the quorum-sensing regulator MvfR (PqsR) using a benzamide-benzimidazole compound interferes with biofilm formation and potentiates biofilm sensitivity to antibiotics. Such a strategy could have great potential against persistence in diverse environments.
摘要
生物膜有助于其在生物和非生物表面存活，并因其对抗生素的高度耐受性而构成重大临床威胁。因此，发现抗生物膜剂可能具有很大的前景。我们表明，使用苯甲酰胺-苯并咪唑化合物抑制群体感应调节剂 MvfR（PqsR）的药理抑制作用会干扰生物膜的形成，并增强生物膜对抗生素的敏感性。这种策略在应对不同环境中的持久性方面可能具有巨大的潜力。
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