Zhang John H, Obenaus Andre, Liebeskind David S, Tang Jiping, Hartman Richard, Pearce William J
1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.
2 Neurovascular Imaging Research Core and Department of Neurology, UCLA, CA, USA.
J Cereb Blood Flow Metab. 2017 Dec;37(12):3818-3823. doi: 10.1177/0271678X17732695. Epub 2017 Sep 19.
Recirculation, from arterial inflow routes through venous outflow pathways, was conceptualized in stroke research 50 years ago. As new technologies were developed, blocked arteries could be reopened, capillaries could be reperfused, and the use of recanalization and reperfusion grew to dominate therapeutic strategies. These approaches overwhelmingly focused on restoration of arterial and capillary inflow, but not on veins even though venous disorders may initiate or exacerbate brain injury. In this commentary, we advance the term "recirculation" after "recanalization" and "reperfusion" as a primary concept of stroke pathophysiology that targets the restoration of both the arterial and venous cerebral circulations.
50年前，在中风研究中就提出了从动脉流入途径经静脉流出途径的再循环概念。随着新技术的发展，阻塞的动脉可以重新开通，毛细血管可以再灌注，再通和再灌注的应用逐渐主导了治疗策略。这些方法绝大多数都集中在恢复动脉和毛细血管的血流上，而没有关注静脉，尽管静脉紊乱可能引发或加重脑损伤。在这篇评论中，我们在“再通”和“再灌注”之后提出“再循环”这一术语，作为中风病理生理学的一个主要概念，其目标是恢复脑动脉和静脉循环。
