Department of General Surgery, Xuyi People`s Hospital, Xuyi, Jiangsu, China.
Department of Clinical Research Center, Xuyi People`s Hospital, Xuyi, Jiangsu, China.
Anticancer Agents Med Chem. 2018;18(5):702-718. doi: 10.2174/1871520617666170918142811.
Compounds obtained from natural resources have become important candidates in the discovery and development of drugs. Over the past few decades, marine resources have gradually attracted a large amount of attention from researchers, and many compounds with varying structures and activities have been derived from various marine resources. Since the ocean experiences more variable temperatures, lower oxygen levels and less light than the terrestrial environment, marine resources offer a substantial number of organisms that are not available or rarely detected on land.
Researchers expect that they can discover agents from marine organisms that exhibit good activity for diseases. Of the marine compounds acquired, the majority have shown to have good antitumor activity, and range in phases from clinical trials up to being used in the clinic. These natural products operate through different pathways and have unique antitumor effects that include inducing cell apoptosis, inhibiting cell proliferation and influencing cell migration. A variety of drugs have been used for cancer treatment during the last few years, but it has not been possible to greatly extend the survival time of advanced cancer patients. In addition, researchers are actively looking for compounds to overcome problems that include a lack of effective drugs to control the transfer of cancer cells and the development of drug-resistant microbes.
Here, we summarize the marine natural products that have been obtained over the past few years, and analyze their antitumor effects and mechanisms. Our research will provide a significant basis for anticancer drug screening and development.
从自然资源中获得的化合物已成为发现和开发药物的重要候选物。在过去的几十年中，海洋资源逐渐引起了研究人员的大量关注，并且从各种海洋资源中已经衍生出了许多具有不同结构和活性的化合物。由于海洋经历的温度变化、氧气水平和光照比陆地环境更多变，因此海洋资源提供了大量在陆地不可用或很少检测到的生物。
研究人员期望他们可以从海洋生物中发现对疾病具有良好活性的药剂。在获得的海洋化合物中，大多数具有良好的抗肿瘤活性，其临床试验阶段涵盖了从临床试验到临床应用。这些天然产物通过不同的途径发挥作用，具有独特的抗肿瘤作用，包括诱导细胞凋亡、抑制细胞增殖和影响细胞迁移。在过去的几年中，已经有多种药物用于癌症治疗，但无法大大延长晚期癌症患者的生存时间。此外，研究人员正在积极寻找克服缺乏有效药物控制癌细胞转移和耐药微生物发展等问题的化合物。
在这里，我们总结了过去几年中获得的海洋天然产物，并分析了它们的抗肿瘤作用和机制。我们的研究将为抗癌药物筛选和开发提供重要依据。
