Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Baoshan District Hospital of Integrated Traditional Chinese Medicine of Shanghai, Shanghai, 201203, China.
Curr Pharm Des. 2017;23(34):5136-5162. doi: 10.2174/1381612823666170918120643.
Nonalcoholic fatty liver disease (NAFLD) has become more prevalent worldwide. It is often associated with some metabolic diseases, such as obesity, type 2 diabetes, and metabolic syndrome. With increasing focus on the treatment of fatty liver, much attention has been paid to numerous medicinal herbs and dietary substances to provide a new strategy for NAFLD treatment. The natural active compounds from the herbs or diet have been studied as promising treatments for NAFLD. This study aimed to summarize the use and mechanism of action of natural active compounds in the treatment of NAFLD in the recent 10 years. An updated search was conducted on the PubMed, Web of Science, and Google Scholar databases from 2006 (for studies on silibinin, resveratrol, curcumin, and berberine compounds since 2010). Fifty-nine active compounds for NAFLD treatment were presented in detail in textual form and tabular form according to their chemical classification.
非酒精性脂肪性肝病（NAFLD）在全球范围内变得更为普遍。它通常与一些代谢性疾病有关，如肥胖、2 型糖尿病和代谢综合征。随着对脂肪肝治疗的日益关注，人们对许多草药和膳食物质给予了更多关注，为 NAFLD 的治疗提供了新的策略。草药或饮食中的天然活性化合物已被研究为治疗 NAFLD 的有前途的方法。本研究旨在总结近 10 年来天然活性化合物在治疗 NAFLD 中的应用和作用机制。对 PubMed、Web of Science 和 Google Scholar 数据库进行了更新检索，时间从 2006 年开始（对于研究水飞蓟素、白藜芦醇、姜黄素和小檗碱化合物则从 2010 年开始）。根据其化学分类，以文字形式和表格形式详细介绍了 59 种用于治疗 NAFLD 的活性化合物。
