Ijichi Kei, Murakami Shingo
Department of Otolaryngology-Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
Oncol Lett. 2017 Sep;14(3):3249-3254. doi: 10.3892/ol.2017.6480. Epub 2017 Jun 23.
The present study aimed to establish a strategy for parapharyngeal space (PPS) tumor surgery based on preoperative symptoms, clinical signs, imaging and histological examination. A retrospective cohort study was conducted with 29 adult patients who underwent surgery for primary PPS tumors from 2008-2015. The following data was obtained: Preoperative symptoms of the patient, histological type of the tumor, surgical approach and complications. Of the 29 patients who underwent surgery to remove a PPS tumor, 16 presented with neurogenic tumors and 13 with salivary gland tumors. The most common symptom was the presence of a neck mass. Preoperative computed tomography and magnetic resonance imaging were performed to evaluate the size and location of the tumors. The majority of the salivary gland tumors were located in the prestyloid space, whereas all neurogenic tumor cases were poststyloid. A total of 21 of the 29 patients (72.4%) underwent a preoperative fine needle aspiration (FNAC) examination. FNAC contributed to preoperative diagnosis in 9 of these cases (42.9%). In parotid tumors of the prestyloid space, facial nerve palsy was a common postoperative complication. In the case of neurogenic tumors, a common complication was the postoperative palsy of the nerve of tumor origin. The strategy for PPS surgery, from the preoperative diagnosis to the operative method, remains controversial. The data on pre- and postoperative symptoms, imaging and histological diagnosis, and the selection of surgical method depending on a neurogenic or salivary tumor origin in the present study indicated that improving the method of examination, carefully selecting the method of approach and accurately managing surgery leads to complete tumor removal, and that the use of nerve-preserving techniques may reduce the likelihood of complications.
本研究旨在基于术前症状、临床体征、影像学及组织学检查,制定一项咽旁间隙(PPS)肿瘤手术策略。对29例2008年至2015年接受原发性PPS肿瘤手术的成年患者进行了一项回顾性队列研究。获取了以下数据:患者的术前症状、肿瘤的组织学类型、手术入路及并发症。在29例行PPS肿瘤切除手术的患者中,16例为神经源性肿瘤,13例为涎腺肿瘤。最常见的症状是颈部肿块。术前行计算机断层扫描和磁共振成像以评估肿瘤的大小和位置。大多数涎腺肿瘤位于茎突前间隙,而所有神经源性肿瘤病例均位于茎突后。29例患者中有21例(72.4%)术前行细针穿刺抽吸(FNAC)检查。其中9例(42.9%)FNAC有助于术前诊断。在茎突前间隙的腮腺肿瘤中,面神经麻痹是常见的术后并发症。对于神经源性肿瘤,常见并发症是肿瘤起源神经的术后麻痹。从术前诊断到手术方法,PPS手术策略仍存在争议。本研究中关于术前和术后症状、影像学及组织学诊断,以及根据神经源性或涎腺肿瘤起源选择手术方法的数据表明,改进检查方法、谨慎选择入路方法及精确管理手术可实现肿瘤的完整切除,并且使用保留神经技术可能会降低并发症的发生率。