Joshi Poonam, Joshi Kamal Deep, Nair Sudhir, Bhati Muddasir, Nair Deepa, Bal Munita, Joshi Amit, Mummudi Naveen, Tuljapurkar Vidisha, Chaukar Devendra A, Chaturvedi Pankaj
Department of Head and Neck Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
South Asian J Cancer. 2021 Nov 24;10(3):167-171. doi: 10.1055/s-0041-1731580. eCollection 2021 Sep.
Tumors of parapharyngeal space (PPS) are rare and histologically diverse. The management of these tumors requires diligent assessment and planning with due consideration of various anatomical and pathological aspects of the lesion. This retrospective study aims to present our experiences in the clinical and pathological aspects of PPS tumors with a critical evaluation of management. Retrospective analytical study. The electronic medical records of 60 cases of PPS tumors, managed surgically from 2007 to 2017, were reviewed and analyzed using SPSS 22 software. The mean follow-up duration was 44 months. The mean age was 45 years with a male-to-female ratio of 1.7 (38:22). The majority of the tumors were benign (71.7%) and the most common presentation being upper neck mass or oropharyngeal mass. Histologically, neurogenic tumors were most common (43.3%) PPS tumors, followed by tumors of salivary gland origin. Magnetic resonance imaging was used as a diagnostic modality in 70% of cases, and computed tomography scan and positron emission tomography/CT were used in 26.7 and 3.3% of cases, respectively. In our study, the diagnostic accuracy of fine-needle aspiration cytology was 71% for benign and 47% for malignant lesions. The most common approach for surgery used was transcervical (72%). The study reveals that cranial nerve palsy is the most common complication associated with PPS tumors. Completely resected, malignant tumors originating within PPS have a good prognosis, as compared with tumors extending or metastasized to PPS.
咽旁间隙（PPS）肿瘤较为罕见，组织学类型多样。这些肿瘤的治疗需要认真评估并制定计划，同时充分考虑病变的各种解剖学和病理学特征。本回顾性研究旨在介绍我们在PPS肿瘤临床和病理学方面的经验，并对治疗进行批判性评估。回顾性分析研究。使用SPSS 22软件对2007年至2017年期间接受手术治疗的60例PPS肿瘤的电子病历进行了回顾和分析。平均随访时间为44个月。平均年龄为45岁，男女比例为1.7（38:22）。大多数肿瘤为良性（71.7%），最常见的表现为上颈部肿块或口咽肿块。组织学上，神经源性肿瘤是最常见的PPS肿瘤（43.3%），其次是涎腺源性肿瘤。70%的病例使用磁共振成像作为诊断手段，26.7%和3.3%的病例分别使用计算机断层扫描和正电子发射断层扫描/计算机断层扫描。在我们的研究中，细针穿刺细胞学检查对良性病变的诊断准确率为71%，对恶性病变的诊断准确率为47%。最常用的手术入路是经颈入路（72%）。研究表明，颅神经麻痹是与PPS肿瘤相关的最常见并发症。与延伸至或转移至PPS的肿瘤相比，起源于PPS的完全切除的恶性肿瘤预后良好。
