基因组印迹超越 DNA 甲基化：母系组蛋白的作用。

Genomic imprinting beyond DNA methylation: a role for maternal histones.

机构信息

Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.

Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.

出版信息

Genome Biol. 2017 Sep 19;18(1):177. doi: 10.1186/s13059-017-1317-9.

DOI:10.1186/s13059-017-1317-9

PMID:28927436

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5605981/

Abstract

Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also confer imprinting.

摘要

配子中 DNA 甲基化状态的遗传决定了哺乳动物的基因组印记。一项新的研究表明，卵母细胞中的抑制性染色质也可以赋予印记。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a43d/5605981/ed46a5a2c1ec/13059_2017_1317_Fig1_HTML.jpg

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基因组印迹超越 DNA 甲基化：母系组蛋白的作用。

Genomic imprinting beyond DNA methylation: a role for maternal histones.

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基因组印迹超越 DNA 甲基化：母系组蛋白的作用。

Genomic imprinting beyond DNA methylation: a role for maternal histones.

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