Institute of Public Health Charité, Universitätsmedizin Berlin, Berlin, Germany.
J Ren Nutr. 2017 Nov;27(6):375-380. doi: 10.1053/j.jrn.2017.07.005. Epub 2017 Sep 18.
Correct determination of glomerular filtration rate (GFR) as an indicator of kidney function bears great importance because clinical decision-making depends on it at many occasions. During the last years, a huge body of literature has been published on estimation and measurement of GFR. The increasing pace with which novel estimation formulae, current and newer biomarkers, assay standardization procedures as well as invasive measurement methods of GFR were published, has been overwhelming for many clinicians. This concise review summarizes central issues in determining kidney function by listing some of the most important publications. It explains fundamental principles in GFR estimation and measurement, the influence of clinical characteristics on endogenous biomarkers, and obstacles in biomarker assessment. Thus, it is thought to be a guide for clinicians through the confusing jungle of GFR determination.
正确确定肾小球滤过率（GFR）作为肾功能的指标非常重要，因为在许多情况下，临床决策都依赖于此。近年来，大量关于 GFR 的估计和测量的文献已经发表。新型估计公式、当前和更新的生物标志物、检测标准化程序以及 GFR 的有创测量方法的发布速度之快，令许多临床医生感到不知所措。这篇简明的综述通过列出一些最重要的出版物，总结了确定肾功能的核心问题。它解释了 GFR 估计和测量的基本原理、临床特征对内源性生物标志物的影响以及生物标志物评估中的障碍。因此，它被认为是临床医生在 GFR 测定的困惑丛林中的指南。
