Lippert T H, Schneider-Zeh S, Voelter W
Department of Obstetrics and Gynecology, University of Tübingen, FRG.
Int J Clin Pharmacol Ther Toxicol. 1987 Oct;25(10):565-6.
In uterine motility tests in virgin rats, the inhibitory action of the peptide hormone relaxin has been compared with the actions of fenoterol and etilefrine. At molecular levels, relaxin and fenoterol showed similar uterine inhibitory activity. Etilefrine was markedly less effective in inducing uterine relaxation. By pretreatment with propranolol, the inhibitory action of both fenoterol and etilefrine could be prevented but not the tocolytic effect of relaxin. Etilefrine, in higher doses, developed alpha-receptor activity as demonstrated by resumed uterine contractions. The doses required to induce beta 2- and alpha-activities differed by a factor of approximately 4,000.
在对未交配大鼠进行子宫活动测试时，已将肽激素松弛素的抑制作用与非诺特罗和乙基肾上腺素的作用进行了比较。在分子水平上，松弛素和非诺特罗表现出相似的子宫抑制活性。乙基肾上腺素在诱导子宫松弛方面明显效果较差。通过用普萘洛尔预处理，可以防止非诺特罗和乙基肾上腺素的抑制作用，但不能防止松弛素的安胎作用。高剂量的乙基肾上腺素表现出α受体活性，这可通过子宫收缩恢复来证明。诱导β2活性和α活性所需的剂量相差约4000倍。
