Lessing J B, Brenner S H, Weiss G
Obstet Gynecol. 1984 Jul;64(1):97-100.
The balance between relaxin and prolactin has been suggested to be significant in the control of uterine activity during pregnancy. The current study was designed to determine the effect of rat prolactin on rat uterine horn segment contractility and its interaction with relaxin. Rat uterine segments mounted on a smooth muscle transducer were treated sequentially with prolactin and relaxin, and stimulated electrically. No stimulatory effect of prolactin was noted. Relaxin-inhibited uterine horn segment activity was not altered by prolactin. The reported stimulatory effect of prolactin may have been a pharmacologic effect of human prolactin on rat uterine horn segments, or may have resulted from contaminants in the preparations used.
松弛素和催乳素之间的平衡被认为在孕期子宫活动的控制中具有重要意义。本研究旨在确定大鼠催乳素对大鼠子宫角段收缩性的影响及其与松弛素的相互作用。将安装在平滑肌换能器上的大鼠子宫段依次用催乳素和松弛素处理，并进行电刺激。未观察到催乳素的刺激作用。催乳素并未改变松弛素抑制的子宫角段活动。所报道的催乳素的刺激作用可能是人类催乳素对大鼠子宫角段的药理作用，或者可能是所用制剂中的污染物所致。
