Thyroid SectionEndocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Department of Internal MedicineUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
Endocr Relat Cancer. 2017 Nov;24(11):R367-R385. doi: 10.1530/ERC-17-0192.
Thyroid hormones (TH) are critical regulators of several physiological processes, which include development, differentiation and growth in virtually all tissues. In past decades, several studies have shown that changes in TH levels caused by thyroid dysfunction, disruption of deiodinases and/or thyroid hormone receptor (TR) expression in tumor cells, influence cell proliferation, differentiation, survival and invasion in a variety of neoplasms in a cell type-specific manner. The function of THs and TRs in neoplastic cell proliferation involves complex mechanisms that seem to be cell specific, exerting effects via genomic and nongenomic pathways, repressing or stimulating transcription factors, influencing angiogenesis and promoting invasiveness. Taken together, these observations indicate an important role of TH status in the pathogenesis and/or development of human neoplasia. Here, we aim to present an updated and comprehensive picture of the accumulated knowledge and the current understanding of the potential role of TH status on the different hallmarks of the neoplastic process.
甲状腺激素 (TH) 是许多生理过程的关键调节剂，包括几乎所有组织的发育、分化和生长。在过去的几十年中，多项研究表明，甲状腺功能障碍引起的 TH 水平变化、脱碘酶的破坏以及/或肿瘤细胞中甲状腺激素受体 (TR) 的表达，以细胞类型特异性的方式影响多种肿瘤中的细胞增殖、分化、存活和侵袭。THs 和 TRs 在肿瘤细胞增殖中的功能涉及复杂的机制，这些机制似乎具有细胞特异性，通过基因组和非基因组途径发挥作用，抑制或刺激转录因子，影响血管生成并促进侵袭性。综上所述，这些观察结果表明 TH 状态在人类肿瘤发生和/或发展中的重要作用。在这里，我们旨在呈现一个关于 TH 状态对肿瘤发生过程中不同特征的潜在作用的积累知识和当前理解的最新和全面的图景。
