心脏型脂肪酸结合蛋白能否预测小儿心脏手术后的临床结局？
Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?
作者信息
Evers Egmond S, Walavalkar Varsha, Pujar Suresh, Balasubramanian Latha, Prinzen Frits W, Delhaas Tammo, Vanagt Ward Y, Maiya Shreesha
机构信息
Department of Physiology and Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Department of Pedicatric Cardiology, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.
出版信息
Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):245-247. doi: 10.4103/apc.APC_33_17.
INTRODUCTION
The early identification of vulnerable pediatric cardiac surgery patients can help clinicians provide them with timely support. Heart-type fatty acid-binding protein. (H-FABP) is an early biomarker of myocardial injury in acute myocardial infarction in adults. In this study, we evaluated the correlations between postoperative H-FABP, creatine kinase-myocardial band (CK-MB), troponin-I, total bypass time, and clinical outcomes.
METHODS
In 32 pediatric patients that underwent ventricular septal defect. closure we measured H-FABP, troponin-I and CK-MB preoperatively and 1, 3, and 6 h after aortic declamping. Spearman's Rho correlations were calculated between laboratory and clinical parameters including inotropic support duration, aortic cross-clamp time, total bypass time, ventilation-weaning-time, and total Intensive Care Unit stay.
RESULTS
H-FABP, CK-MB, troponin-I, and total bypass time have a similarly weak to moderate correlation with clinical outcome measures.
CONCLUSIONS
The predictive value of H-FABP for clinical outcome is not stronger than that of CK-MB, Troponin-I, or bypass times.
引言
早期识别易发生危险的小儿心脏手术患者有助于临床医生及时为他们提供支持。心脏型脂肪酸结合蛋白（H-FABP）是成人急性心肌梗死中心肌损伤的早期生物标志物。在本研究中，我们评估了术后H-FABP、肌酸激酶同工酶（CK-MB）、肌钙蛋白I、总体外循环时间与临床结局之间的相关性。
方法
在32例行室间隔缺损修补术的小儿患者中，我们在术前以及主动脉钳夹松开后1、3和6小时测量了H-FABP、肌钙蛋白I和CK-MB。计算了实验室参数与临床参数之间的Spearman等级相关系数，临床参数包括正性肌力支持持续时间、主动脉阻断时间、总体外循环时间、脱机时间和重症监护病房总住院时间。
结果
H-FABP、CK-MB、肌钙蛋白I和总体外循环时间与临床结局指标的相关性同样较弱至中等。
结论
H-FABP对临床结局的预测价值并不强于CK-MB、肌钙蛋白I或体外循环时间。
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