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一名患有永久性交界性反复性心动过速的早产儿的氟卡尼毒性反应

Flecainide toxicity in a preterm neonate with permanent junctional reciprocating tachycardia.

作者信息

Karmegaraj Balaganesh, Menon Danish, Prabhu Mukund A, Vaidyanathan Balu

机构信息

Department of Pediatric Cardiology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.

Department of Adult Cardiology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.

出版信息

Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):288-292. doi: 10.4103/apc.APC_31_17.

DOI:10.4103/apc.APC_31_17
PMID:28928617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5594942/
Abstract

We report a case of flecainide toxicity in a premature neonate with permanent junctional reciprocating tachycardia which was managed successfully by reversal of the sodium blockade with intravenous sodium bicarbonate and supportive care. This report highlights the importance of strict supervision and monitoring while administering antiarrhythmic drugs in neonates and prompt institution of appropriate remedial action for treatment when toxicity is suspected.

摘要

我们报告了一例患有永久性交界性折返性心动过速的早产新生儿出现氟卡尼中毒的病例，通过静脉注射碳酸氢钠逆转钠阻滞并给予支持性护理成功处理了该病例。本报告强调了在给新生儿使用抗心律失常药物时进行严格监督和监测的重要性，以及在怀疑中毒时及时采取适当补救措施进行治疗的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/dbe24d1841b1/APC-10-288-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/3a9ff02df201/APC-10-288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/612cf4fc0774/APC-10-288-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/adadf694a049/APC-10-288-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/dbe24d1841b1/APC-10-288-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/3a9ff02df201/APC-10-288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/612cf4fc0774/APC-10-288-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/adadf694a049/APC-10-288-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2286/5594942/dbe24d1841b1/APC-10-288-g004.jpg

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本文引用的文献

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Successful treatment of flecainide-induced cardiac arrest with extracorporeal membrane oxygenation in the ED.在急诊科应用体外膜肺氧合成功治疗氟卡尼诱发的心脏骤停。
Am J Emerg Med. 2015 Oct;33(10):1542.e1-2. doi: 10.1016/j.ajem.2015.07.054. Epub 2015 Jul 29.
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Permanent junctional reciprocating tachycardia in children: a multicenter experience.儿童永久性交界性反复性心动过速：一项多中心研究经验
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Hypertonic sodium bicarbonate versus intravenous lipid emulsion in a rabbit model of intravenous flecainide toxicity: no difference, no sink.
Case Files from the University of California San Diego Medical Toxicology Fellowship: Neonatal Flecainide Toxicity from an Accidental Dosing Error.
加利福尼亚大学圣地亚哥分校医学毒理学奖学金项目病例档案：因意外用药剂量错误导致的新生儿氟卡尼中毒
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Case report: Use of therapeutic drug monitoring and pharmacogenetic testing as opportunities to individualize care in a case of flecainide toxicity after fetal supraventricular tachycardia.病例报告：胎儿室上性心动过速后氟卡尼中毒病例中，利用治疗药物监测和药物遗传学检测实现个体化治疗
Front Pediatr. 2023 Jun 28;11:1168619. doi: 10.3389/fped.2023.1168619. eCollection 2023.
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Clinical presentation, management, and postnatal outcomes of fetal tachyarrhythmias: A 10-year single-center experience.胎儿心律失常的临床表现、管理及产后结局：一项为期10年的单中心经验
Ann Pediatr Cardiol. 2018 Jan-Apr;11(1):34-39. doi: 10.4103/apc.APC_102_17.
高渗性碳酸氢钠与静脉用脂肪乳剂在静脉用氟卡尼中毒兔模型中的作用比较：无差异，无解毒作用。
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J Emerg Med. 2013 Apr;44(4):781-3. doi: 10.1016/j.jemermed.2012.07.050. Epub 2012 Sep 13.
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