Savarino V, Picciotto A, Magnolia M R, Scalabrini P, Mela G S, Celle G
Instituto Scientifico Medicina Interna, Università di Genova, Italy.
J Clin Pharmacol. 1987 Oct;27(10):790-3. doi: 10.1002/j.1552-4604.1987.tb02998.x.
The antisecretory efficacy of a single bedtime dose of famotidine, a new potent H2-receptor antagonist, was evaluated by means of continuous 24-hour intragastric pH monitoring. Of 20 patients with duodenal ulcers, ten randomly received famotidine 40 mg at 10 PM and ten were monitored without medication for control. Famotidine regimen led to a remarkable reduction of gastric acidity in patients who were treated for duodenal ulcer and the drug-induced pH levels were significantly different (P less than .0001) from those of untreated controls. The antisecretory action lasted for 12 hours, which comprised the nocturnal period, whereas no important difference was found between the two groups for the most part of the daytime. The drug was able to keep intragastric pH above 4 units during almost 50% of the whole 24-hour period. These results confirm that famotidine is a powerful and long-acting H2 blocker that relieves gastric acidity during the night and morning hours when administered as a single bedtime dose of 40 mg.
通过连续24小时胃内pH监测，评估了新型强效H2受体拮抗剂法莫替丁单次睡前剂量的抑酸效果。20例十二指肠溃疡患者中，10例在晚上10点随机接受40毫克法莫替丁治疗，10例未用药作为对照进行监测。法莫替丁治疗方案使十二指肠溃疡患者的胃酸显著降低，药物诱导的pH水平与未治疗对照组相比有显著差异（P小于0.0001）。抑酸作用持续12小时，包括夜间时段，而在白天的大部分时间里两组之间未发现重要差异。该药物在整个24小时期间近50%的时间内能够使胃内pH保持在4个单位以上。这些结果证实，法莫替丁是一种强效长效H2阻滞剂，当作为40毫克单次睡前剂量给药时，可在夜间和早晨时段减轻胃酸。
