Stern R, Sorenson J, Wurster-Hill D H, Cornwell G G, McIntyre O R
Am J Hematol. 1979;6(2):155-61. doi: 10.1002/ajh.2830060208.
A patient with chronic myelogenous leukemia (CML) had a Philadelphia chromosome (Ph') [t(9q+;22q-)] in all cells and trisomy C in 13% of cells (later determined to be trisomy 8) at the time of diagnosis. After 21 months of intermittent treatment with busulfan, the acute phase developed with the appearance of an additional abnormality (trisomy ? 19). During a complete remission and reconversion to the chronic phase, trisomies 8 and ? 19 DISAPPEARed, although the Ph' remained. Following a period of marked thrombocytosis, a second relapse occurred with the reappearance of both marker chromosomes.
一名慢性粒细胞白血病（CML）患者在诊断时所有细胞均有费城染色体（Ph'）[t(9q+;22q-)]，13%的细胞存在三体C（后来确定为三体8）。在用白消安进行21个月的间歇治疗后，急性期出现，伴有另一种异常（三体？19）。在完全缓解并重新转变为慢性期时，三体8和？19消失，尽管Ph'仍然存在。在一段明显的血小板增多期后，第二次复发，两种标记染色体再次出现。
