Stoll C
Pathol Biol (Paris). 1982 Nov;30(9):755-8.
The chromosomal involvement in the development of malignancy in chronic myeloid leukemia is not a random event. A second Ph1, a trisomy 8, an isochromosome 17q, a trisomy 17 are the main abnormalities. These aberrations use to occur as a karyotypic evolution, either simple or complicated. An extra-medullary development of blastic transformation was demonstrated by chromosomal analysis. It is difficult to demonstrate a correlation between chromosomal abnormalities and clinical evolution in the acute phase of chronic myeloid leukemia.
慢性髓性白血病中染色体异常在恶性肿瘤发生发展过程中并非随机事件。第二个费城染色体（Ph1）、8号染色体三体、17号染色体长臂等臂染色体、17号染色体三体是主要的异常情况。这些畸变常作为核型演变出现，可为简单型或复杂型。染色体分析证实了急变期髓外造血的发生。在慢性髓性白血病急性期，很难证明染色体异常与临床病程之间存在相关性。
