Peng Shan, Wang Yahua, Li Na, Li Chong
College of Pharmaceutical Sciences, Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Southwest University, Chongqing 400715, China.
Chem Commun (Camb). 2017 Oct 10;53(81):11114-11117. doi: 10.1039/c7cc05894b.
The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular uptake and permeability in target tissues for tumor-targeted drug delivery.
广泛存在的跨膜螺旋可作为一种新型的结合位点，用于识别相应的膜受体。通过对某些受体的跨膜结构域进行印迹，我们在此报告了聚合物纳米颗粒的构建，该纳米颗粒可在肿瘤靶向药物递送的靶组织中实现增强的细胞摄取和通透性。
