Zhou S-H, Liang X-H, Shao L-N, Yu W-J, Zhao C, Liu M
Department of Blood Group, Dalian Blood Center, Dalian, China.
Department of Clinical Laboratory, Anshan Municipal Central Hospital, Anshan, China.
Int J Immunogenet. 2017 Dec;44(6):337-342. doi: 10.1111/iji.12341. Epub 2017 Sep 20.
Hepatitis C virus (HCV) is a major cause of chronic hepatitis. Previous studies have identified a number of single nucleotide polymorphisms that are associated with HCV infection. Human platelet antigens (HPAs) polymorphisms play an important role in several diseases. Here, we demonstrated the association of the HPA-2, HPA-3, HPA-5 and HPA-15 polymorphisms with susceptibility to HCV infection in Chinese population. Overall, 118 patients with HCV and 167 controls were genotyped for HPAs. There were no significant differences in the allele and genotype frequency distribution for the HPA-3, HPA-5 and HPA-15 systems between the patients with chronic HCV infection and the healthy controls (p > .05). However, the genotype frequency of HPA-2aa was significantly lower, while HPA-2ab/bb was significantly higher in patients than that in the controls (p = .006). The allele frequency of HPA-2a in patients was significantly lower than that in the control group (p = .005). In contrast, HPA-2b in patients was significantly higher than that in the control group (p = .005). We conclude that HPA-2 polymorphism is associated with susceptibility to HCV infection, and individuals carrying the HPA-2b allele may have a higher risk of HCV infection compared with individuals carrying HPA-2a.
丙型肝炎病毒（HCV）是慢性肝炎的主要病因。先前的研究已经确定了一些与HCV感染相关的单核苷酸多态性。人类血小板抗原（HPA）多态性在多种疾病中起重要作用。在此，我们证明了HPA - 2、HPA - 3、HPA - 5和HPA - 15多态性与中国人群对HCV感染的易感性之间的关联。总体而言，对118例HCV患者和167例对照进行了HPA基因分型。慢性HCV感染患者与健康对照之间，HPA - 3、HPA - 5和HPA - 15系统的等位基因和基因型频率分布没有显著差异（p>0.05）。然而，患者中HPA - 2aa的基因型频率显著低于对照组，而HPA - 2ab/bb则显著高于对照组（p = 0.006）。患者中HPA - 2a的等位基因频率显著低于对照组（p = 0.005）。相反，患者中HPA - 2b显著高于对照组（p = 0.005）。我们得出结论，HPA - 2多态性与HCV感染易感性相关，与携带HPA - 2a的个体相比，携带HPA - 2b等位基因的个体可能有更高的HCV感染风险。
