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人参对肝损伤:是友还是敌?

Ginseng for Liver Injury: Friend or Foe?

作者信息

Kim Tae-Woo

机构信息

Graduate School of Medicine, School of Medicine, CHA University, Seongnam-shi, Gyunggi-do 13488, Korea.

出版信息

Medicines (Basel). 2016 Dec 17;3(4):33. doi: 10.3390/medicines3040033.

DOI:10.3390/medicines3040033
PMID:28930143
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456240/
Abstract

sp., including Meyer, L., or (Burk.) FH Chen, have been used as functional foods or for traditional Chinese medicine for diabetes, inflammation, stress, aging, hepatic injury, and cancer. In recent decades, a number of both in vitro and in vivo experiments as well as human studies have been conducted to investigate the efficacy and safety of various types of ginseng samples and their components. Of these, the hepatoprotective and hepatotoxic effects of ginseng and their ginsenosides and polysaccharides are reviewed and summarized.

摘要

人参属植物,包括迈耶氏人参、L. 人参或(伯克氏人参)FH 陈,已被用作功能性食品或用于治疗糖尿病、炎症、压力、衰老、肝损伤和癌症的传统中药。近几十年来,已经进行了大量的体外和体内实验以及人体研究,以调查各种人参样品及其成分的功效和安全性。其中,对人参及其人参皂苷和多糖的肝保护和肝毒性作用进行了综述和总结。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e013/5456240/8b076e65c4f1/medicines-03-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e013/5456240/7aa6bc8fb4ef/medicines-03-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e013/5456240/8b076e65c4f1/medicines-03-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e013/5456240/7aa6bc8fb4ef/medicines-03-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e013/5456240/8b076e65c4f1/medicines-03-00033-g002.jpg

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本文引用的文献

1
Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs.传统中医与草药肝毒性:RUCAM及微小RNA等新型诊断生物标志物的作用
Medicines (Basel). 2016 Jul 19;3(3):18. doi: 10.3390/medicines3030018.
2
Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice.给予三七多糖可延长荷H22肿瘤小鼠的生存期。
Onco Targets Ther. 2016 Jun 8;9:3433-41. doi: 10.2147/OTT.S79427. eCollection 2016.
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Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update.
一种不良的药物相互作用:人参和阿托伐他汀相互作用导致潜在肝损伤的罕见病例。
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对乙酰氨基酚诱导的肝毒性:全面更新。
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Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.草药肝毒性:临床特征与列表汇编
Int J Mol Sci. 2016 Apr 27;17(5):588. doi: 10.3390/ijms17050588.
5
Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis.高丽参(Panax ginseng C.A. Meyer)中的人参皂甙 Rc 可减轻胃炎、肝炎和关节炎的炎症症状。
Am J Chin Med. 2016;44(3):595-615. doi: 10.1142/S0192415X16500336. Epub 2016 Apr 24.
6
[Effect of ginsenoside total saponinon on regulation of P450 of livers of rats after γ-ray irradiation].[人参总皂苷对γ射线照射后大鼠肝脏P450调控的影响]
Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):4037-43.
7
Oral subchronic toxicity evaluation of a novel antitumor agent 25-methoxydammarane-3, 12, 20-triol from Panax notoginseng in Sprague-Dawley rats.三七中新型抗肿瘤药物25-甲氧基达玛烷-3, 12, 20-三醇对Sprague-Dawley大鼠的口服亚慢性毒性评价
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8
Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients.肝胆胰:1985例患者中药与西药所致肝损伤的比较
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The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.丹参酚酸B与人参皂苷Rg1联合应用对小鼠的安全性评价
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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum.基于证据链的肝损伤中药相关性鉴定:以著名的肝修复中药何首乌为例。
Front Med. 2015 Dec;9(4):457-67. doi: 10.1007/s11684-015-0417-8. Epub 2015 Oct 12.