Wang Ting, Guo Rixin, Zhou Guohong, Zhou Xidan, Kou Zhenzhen, Sui Feng, Li Chun, Tang Liying, Wang Zhuju
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, No. 16, Nanxiaojie, Dongzhimennei Ave., Beijing 100700, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, No. 16, Nanxiaojie, Dongzhimennei Ave., Beijing 100700, China.
J Ethnopharmacol. 2016 Jul 21;188:234-58. doi: 10.1016/j.jep.2016.05.005. Epub 2016 May 3.
Panax notoginseng (Burk.) F.H. Chen is a widely used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is distributed primarily in the southwest of China, has wide-ranging pharmacological effects and can be used to treat cardiovascular diseases, pain, inflammation and trauma as well as internal and external bleeding due to injury.
This paper provides up-to-date information on investigations of this plant, including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. The possible uses and perspectives for future investigation of this plant are also discussed.
The relevant information on Panax notoginseng (Burk.) F.H. Chen was collected from numerous resources, including classic books about Chinese herbal medicine, and scientific databases, including Pubmed, SciFinder, ACS, Ebsco, Elsevier, Taylor, Wiley and CNKI.
More than 200 chemical compounds have been isolated from Panax notoginseng (Burk.) F.H. Chen, including saponins, flavonoids and cyclopeptides. The plant has pharmacological effects on the cardiovascular system, immune system as well as anti-inflammatory, anti-atherosclerotic, haemostatic and anti-tumour activities, etc.
Panax notoginseng is a valuable traditional Chinese medical herb with multiple pharmacological effects. This review summarizes the botany, ethnopharmacology, phytochemistry, pharmacology and toxicology of P. notoginseng, and presents the constituents and their corresponding chemical structures found in P. notoginseng comprehensively for the first time. Future research into its phytochemistry of bio-active components should be performed by using bioactivity-guided isolation strategies. Further work on elucidation of the structure-function relationship among saponins, understanding of multi-target network pharmacology of P. notoginseng, as well as developing its new clinical usage and comprehensive utilize will enhance the therapeutic potentials of P. notoginseng.
三七（Panax notoginseng (Burk.) F.H. Chen）是一种在中国广泛使用的传统中药，在中国被称为三七或田七。这种植物主要分布在中国西南部，具有广泛的药理作用，可用于治疗心血管疾病、疼痛、炎症和创伤，以及因损伤引起的内外出血。
本文提供了关于这种植物研究的最新信息，包括其植物学、民族药理学、植物化学、药理学和毒理学。还讨论了该植物未来研究的可能用途和前景。
从众多资源中收集了有关三七（Panax notoginseng (Burk.) F.H. Chen）的相关信息，包括有关中草药的经典书籍以及科学数据库，如Pubmed、SciFinder、ACS、Ebsco、Elsevier、Taylor、Wiley和CNKI。
已从三七（Panax notoginseng (Burk.) F.H. Chen）中分离出200多种化合物，包括皂苷、黄酮类化合物和环肽。该植物对心血管系统、免疫系统具有药理作用，还具有抗炎、抗动脉粥样硬化、止血和抗肿瘤等活性。
三七是一种具有多种药理作用的珍贵传统中药。本综述总结了三七的植物学、民族药理学、植物化学、药理学和毒理学，并首次全面介绍了三七中发现的成分及其相应的化学结构。未来应采用生物活性导向分离策略对其生物活性成分的植物化学进行研究。进一步阐明皂苷之间的结构-功能关系、理解三七的多靶点网络药理学，以及开发其新的临床用途和综合利用，将提高三七的治疗潜力。
