Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda 20892, Maryland, USA.
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda 20892, Maryland, USA,
Front Biosci (Landmark Ed). 2018 Jan 1;23(5):811-836. doi: 10.2741/4618.
Drugs and food both exert a rewarding effect through the firing of dopamine neurons in the ventral tegmental area, resulting in the release of dopamine into the nucleus accumbens and effects on the mesolimbic pathway. Here, we review the neuroimaging literature to consider the validity of food addiction and the common neurobiological mechanisms that overlap in food and drug addiction. This review paper focuses on findings from Positron Emission Tomography (PET), functional Magnetic Resonance Imaging (fMRI) and structural imaging studies, as well as evidence from neuroimaging studies of bariatric surgery and pharmacological interventions on obese individuals. We examine not only functional and structural changes in the mesolimbic pathways, but also in other frontal areas shown to be involved in drug addiction, including the prefrontal cortex, orbitofrontal cortex and anterior cingulate cortex, as well as changes in neurotransmitter systems beyond dopaminergic systems.
药物和食物都会通过腹侧被盖区的多巴胺神经元的兴奋产生奖赏效应，导致多巴胺释放到伏隔核，并对中脑边缘通路产生影响。在这里，我们回顾了神经影像学文献，以考虑食物成瘾的有效性以及食物成瘾和药物成瘾之间重叠的常见神经生物学机制。这篇综述论文重点介绍了正电子发射断层扫描（PET）、功能磁共振成像（fMRI）和结构成像研究的结果，以及肥胖个体接受减肥手术和药物干预的神经影像学研究的证据。我们不仅检查了中脑边缘通路的功能和结构变化，还检查了其他被证明与药物成瘾有关的额前区域，包括前额叶皮层、眶额皮层和前扣带皮层，以及除多巴胺能系统之外的神经递质系统的变化。
