Jacobs I, Stabile I, Bridges J, Kemsley P, Reynolds C, Grudzinskas J, Oram D
Department of Obstetrics and Gynaecology, London Hospital.
Lancet. 1988 Feb 6;1(8580):268-71. doi: 10.1016/s0140-6736(88)90351-0.
1010 postmenopausal women were recruited for an ovarian cancer screening programme incorporating serum CA-125 measurement and vaginal examination as initial tests and real-time ultrasonography as a secondary procedure in selected cases. The normal range for serum CA-125 in postmenopausal women was established. The specificity for ovarian cancer of serum CA-125 measurement and vaginal examination were 97.0% and 97.3%, respectively. The combinations of serum CA-125 measurement with ultrasound and vaginal examination with ultrasound achieved specificities of 99.8% and 99.0%, respectively. 100% specificity was achieved by serum CA-125 measurement with vaginal examination and by the combination of all three tests. The findings indicate that no individual screening test has acceptable specificity for ovarian cancer in postmenopausal women. However, the combination of CA-125 measurement with ultrasound did achieve acceptable specificity and offers the most hope of a specific and sensitive method for early detection.
1010名绝经后女性被招募参加一项卵巢癌筛查项目，该项目将血清CA - 125检测和阴道检查作为初始检测手段，并在特定病例中将实时超声检查作为辅助检查。确定了绝经后女性血清CA - 125的正常范围。血清CA - 125检测和阴道检查对卵巢癌的特异性分别为97.0%和97.3%。血清CA - 125检测与超声检查联合以及阴道检查与超声检查联合的特异性分别达到了99.8%和99.0%。血清CA - 125检测与阴道检查联合以及三项检查全部联合均达到了100%的特异性。研究结果表明，对于绝经后女性卵巢癌筛查，没有任何一项单独的筛查检测具有可接受的特异性。然而，CA - 125检测与超声检查联合确实达到了可接受的特异性，并为早期检测提供了最有希望的特异性和敏感性方法。
