阿尔茨海默病氧化应激评估：临床环境研究。
Oxidative Stress Assessment in Alzheimer's Disease: A Clinic Setting Study.
机构信息
1 Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
出版信息
Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):35-41. doi: 10.1177/1533317517728352. Epub 2017 Sep 21.
BACKGROUND
Oxidative stress (OS) is a physiological age-related brain process, dramatically overexpressed in neurodegenerative disorders like Alzheimer's disease (AD). Nevertheless, the pathophysiological role of OS in AD pathology has not been clarified yet. OS as a biomarker for AD is a controversial issue. A comparison of previous data is difficult due to a remarkable methodological variability. Most of the previous studies have shown higher levels of OS markers and lower antioxidant power in patients with dementia when compared to mild cognitive impairment (MCI) and healthy controls.
METHODS
We followed a strict protocol in order to limit intrasite variability of OS assessment. In addition, we have taken into account possible confounding factors.
RESULTS
In agreement with previous reports, we found both lower plasmatic OS and higher plasmatic antioxidant defenses when comparing patients with AD having dementia that is stably treated to patients with MCI-AD.
DISCUSSION
A speculative hypothesis based on correlative data is provided.
背景
氧化应激（OS）是一种与年龄相关的生理性大脑过程，在阿尔茨海默病（AD）等神经退行性疾病中显著过度表达。然而，OS 在 AD 病理中的病理生理作用尚未阐明。OS 作为 AD 的生物标志物是一个有争议的问题。由于方法学的显著可变性，以前数据的比较比较困难。大多数先前的研究表明，与轻度认知障碍（MCI）和健康对照组相比，痴呆症患者的 OS 标志物水平更高，抗氧化能力更低。
方法
我们遵循严格的方案，以限制 OS 评估的站点内变异性。此外，我们还考虑了可能的混杂因素。
结果
与先前的报告一致，我们发现 AD 痴呆患者的血浆 OS 水平较低，而 MCI-AD 患者的血浆抗氧化防御能力较高。
讨论
基于相关数据提供了一个推测性假说。
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