Gilman R H, Marquis G S, Miranda E, Vestegui M, Martinez H
Johns Hopkins University, Baltimore, Maryland.
Lancet. 1988 Feb 13;1(8581):343-5. doi: 10.1016/s0140-6736(88)91131-2.
In a peri-urban shanty town in Lima, Peru, that was hyperendemic for Giardia lamblia, 44 children aged between 0.9 months and 10 years were effectively treated for Giardia lamblia with tinidazole. Stools were examined weekly in the 6 months after treatment to determine the rate of reinfection, and after reinfection stools continued to be examined. 98% of the children became reinfected with Giardia lamblia within 6 months, and after reinfection stool excretion of the parasite lasted a mean (SD) of 3.2 (3.3) months. The children's mean stool pH and their mean stool fat index was unaffected by Giardia lamblia reinfection. Treatment of all symptomless Giardia lamblia infections in a developing country hyperendemic for the disease is of questionable value because of rapid reinfection.
在秘鲁利马一个贾第虫高度流行的城郊棚户区，44名年龄在0.9个月至10岁之间的儿童接受了替硝唑有效治疗贾第虫感染。治疗后的6个月内每周检查粪便，以确定再感染率，再感染后继续检查粪便。98%的儿童在6个月内再次感染贾第虫，再感染后寄生虫粪便排泄持续时间平均（标准差）为3.2（3.3）个月。儿童的平均粪便pH值和平均粪便脂肪指数不受贾第虫再感染的影响。由于再感染迅速，在一个该病高度流行的发展中国家对所有无症状贾第虫感染进行治疗的价值值得怀疑。
