Schultz S G
Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston 77225, USA.
Am J Physiol. 1998 Jan;274(1):C13-23. doi: 10.1152/ajpcell.1998.274.1.C13.
During the past century, the generally accepted view of the function of biological membranes has evolved from that of a static, inert lipoprotein envelope that simply separates the intracellular machinery from the outside milieu, to that of a dynamic structure that is, in fact, an integral part of that machinery actively involved in homeostasis and bioenergetics. This brief review traces that paradigm shift with special emphasis on the evolution of central concepts in epithelial transport physiology.
在过去的一个世纪里，人们对于生物膜功能的普遍认知已经从一种静态、惰性的脂蛋白包膜（仅仅将细胞内机制与外部环境分隔开来），演变为一种动态结构，实际上它是该机制的一个组成部分，积极参与体内平衡和生物能量学。这篇简短的综述追溯了这一范式转变，特别强调上皮运输生理学核心概念的演变。
