秀丽隐杆线虫作为病毒-宿主相互作用的新兴模型
Caenorhabditis elegans as an Emerging Model for Virus-Host Interactions.
作者信息
Gammon Don B
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
出版信息
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.00509-17. Print 2017 Dec 1.
Abstract
Since 1999, has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of and development of diverse artificial infection models are providing new opportunities to explore virus-host interplay in this powerful model organism.
摘要
自1999年以来，由于其培养简单、遗传易处理且对多种细菌和真菌病原体敏感，已被广泛用于研究微生物与宿主的相互作用。相比之下，线虫中缺乏便捷的病毒感染模型阻碍了病毒研究。最近发现的一种天然病毒病原体以及多种人工感染模型的开发，为在这种强大的模式生物中探索病毒与宿主的相互作用提供了新机会。
相似文献
1
Caenorhabditis elegans as an Emerging Model for Virus-Host Interactions.秀丽隐杆线虫作为病毒-宿主相互作用的新兴模型
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.00509-17. Print 2017 Dec 1.
2
An Evolutionarily Conserved Pathway Essential for Orsay Virus Infection of .一个进化保守的通路对于 Orsay 病毒感染 是必需的。
mBio. 2017 Sep 5;8(5):e00940-17. doi: 10.1128/mBio.00940-17.
3
Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses.新型杆状病毒相关病毒对秀丽隐杆线虫的自然和实验感染。
PLoS Biol. 2011 Jan 25;9(1):e1000586. doi: 10.1371/journal.pbio.1000586.
4
Natural Viruses of Nematodes.线虫的天然病毒。
Annu Rev Genet. 2019 Dec 3;53:313-326. doi: 10.1146/annurev-genet-112618-043756. Epub 2019 Aug 19.
5
The Dietary Restriction-Like Gene , Which Encodes a Putative Serine/Threonine Kinase, Is Essential for Orsay Virus Infection in .该限制饮食样基因，编码一种假定的丝氨酸/苏氨酸激酶，对于 Orsay 病毒在. 中的感染是必需的。
J Virol. 2019 Jan 17;93(3). doi: 10.1128/JVI.01400-18. Print 2019 Feb 1.
6
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans.秀丽隐杆线虫中针对奥赛病毒的抗病毒RNA干扰既不是全身性的，也不是跨代的。
J Virol. 2015 Dec;89(23):12035-46. doi: 10.1128/JVI.03664-14. Epub 2015 Sep 23.
7
Novel insights into virus-host interactions using the model organism C. elegans.利用模式生物秀丽隐杆线虫深入了解病毒-宿主相互作用。
Adv Virus Res. 2023;115:135-158. doi: 10.1016/bs.aivir.2023.03.001. Epub 2023 Apr 3.
8
Punctuated Loci on Chromosome IV Determine Natural Variation in Orsay Virus Susceptibility of Strains Bristol N2 and Hawaiian CB4856.染色体 IV 上的标点基因决定了 Orsay 病毒在 Bristol N2 和 Hawaiian CB4856 两个菌株中的自然变异易感性。
J Virol. 2021 May 24;95(12). doi: 10.1128/JVI.02430-20.
9
Engineering recombinant Orsay virus directly in the metazoan host Caenorhabditis elegans.直接在多细胞动物宿主秀丽隐杆线虫中构建重组奥赛病毒。
J Virol. 2014 Oct;88(20):11774-81. doi: 10.1128/JVI.01630-14. Epub 2014 Jul 30.
10
Characterization of virus-encoded RNA interference suppressors in Caenorhabditis elegans.线虫中病毒编码的 RNA 干扰抑制剂的特性研究。
J Virol. 2013 May;87(10):5414-23. doi: 10.1128/JVI.00148-13. Epub 2013 Mar 6.
引用本文的文献
1
Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model.深入了解病毒与宿主的相互作用：来自秀丽隐杆线虫-奥赛病毒模型的经验教训。
Curr Med Sci. 2025 Apr;45(2):169-184. doi: 10.1007/s11596-025-00004-8. Epub 2025 Mar 3.
2
Utilization of Artificial Intelligence Coupled with a High-Throughput, High-Content Platform in the Exploration of Neurodevelopmental Toxicity of Individual and Combined PFAS.利用人工智能结合高通量、高内涵平台探索全氟辛烷磺酸个体及组合的神经发育毒性
J Xenobiot. 2025 Feb 2;15(1):24. doi: 10.3390/jox15010024.
3
Orsay Virus Infection in Caenorhabditis elegans.秀丽隐杆线虫中的奥尔森病毒感染。
Curr Protoc. 2024 Jul;4(7):e1098. doi: 10.1002/cpz1.1098.
4
Nuclear hormone receptor NHR-49 is an essential regulator of stress resilience and healthy aging in .核激素受体NHR-49是（生物）应激恢复力和健康衰老的重要调节因子。 （注：原句中“in”后面缺少具体内容）
Front Physiol. 2023 Aug 14;14:1241591. doi: 10.3389/fphys.2023.1241591. eCollection 2023.
5
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6-methyladenosine-containing RNA virus.植物 YTHDF 蛋白是抗病毒免疫的直接效应因子，可针对含有 N6-甲基腺苷的 RNA 病毒。
EMBO J. 2023 Sep 18;42(18):e113378. doi: 10.15252/embj.2022113378. Epub 2023 Jul 11.
6
COVID-19 and Multiple Sclerosis: A Complex Relationship Possibly Aggravated by Low Vitamin D Levels.新型冠状病毒肺炎与多发性硬化症：可能因维生素 D 水平低而加重的复杂关系。
Cells. 2023 Feb 21;12(5):684. doi: 10.3390/cells12050684.
7
Developing an empirical model for spillover and emergence: Orsay virus host range in .建立溢出和出现的经验模型：Orsay 病毒在. 中的宿主范围。
Proc Biol Sci. 2022 Sep 28;289(1983):20221165. doi: 10.1098/rspb.2022.1165. Epub 2022 Sep 21.
8
-GlcNAcylation confers protection against infection in through ubiquitination.O-连接的N-乙酰葡糖胺糖基化通过泛素化作用赋予对感染的保护。
RSC Adv. 2018 Jun 26;8(41):23089-23100. doi: 10.1039/c8ra00279g. eCollection 2018 Jun 21.
9
Plant and animal small RNA communications between cells and organisms.动植物细胞和生物之间的小 RNA 通讯。
Nat Rev Mol Cell Biol. 2022 Mar;23(3):185-203. doi: 10.1038/s41580-021-00425-y. Epub 2021 Oct 27.
10
, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms.一种用于研究有益微生物益生菌特性的宿主。 （原文表述不太完整，翻译可能会稍显生硬，建议你检查下完整准确的原文以便获得更理想的译文）
Front Nutr. 2020 Aug 21;7:135. doi: 10.3389/fnut.2020.00135. eCollection 2020.
本文引用的文献
1
The Natural Biotic Environment of .……的自然生物环境 （原文不完整）
Genetics. 2017 May;206(1):55-86. doi: 10.1534/genetics.116.195511.
2
An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes.秀丽隐杆线虫中对病毒感染的一种进化保守的转录反应。
BMC Genomics. 2017 Apr 17;18(1):303. doi: 10.1186/s12864-017-3689-3.
3
RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.RIG-I同源物在病毒小干扰RNA的Dicer依赖性生物合成下游介导抗病毒RNA干扰。
mBio. 2017 Mar 21;8(2):e00264-17. doi: 10.1128/mBio.00264-17.
4
The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.抗病毒 RNA 干扰反应可使秀丽隐杆线虫抵抗致命虫媒病毒感染和垂直传播。
Curr Biol. 2017 Mar 20;27(6):795-806. doi: 10.1016/j.cub.2017.02.004. Epub 2017 Mar 2.
5
Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells.一种五聚体病毒体相关纤维的结构，其在奥赛病毒进入宿主细胞过程中可能发挥作用。
PLoS Pathog. 2017 Feb 27;13(2):e1006231. doi: 10.1371/journal.ppat.1006231. eCollection 2017 Feb.
6
Targeted genome engineering in .在……中的靶向基因组工程
Cell Biosci. 2016 Dec 8;6:60. doi: 10.1186/s13578-016-0125-3. eCollection 2016.
7
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.秀丽隐杆线虫通过渗透应激延长寿命需要氟尿嘧啶脱氧核苷、碱基切除修复、叉头转录因子O和沉默调节蛋白。
Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22.
8
Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.病毒免疫。哺乳动物肠道中病毒感染与免疫的跨界调控。
Science. 2016 Jan 15;351(6270). doi: 10.1126/science.aad5872. Epub 2016 Jan 14.
9
Local and long-range activation of innate immunity by infection and damage in C. elegans.秀丽隐杆线虫中感染和损伤对先天免疫的局部和远距离激活
Curr Opin Immunol. 2016 Feb;38:1-7. doi: 10.1016/j.coi.2015.09.005. Epub 2015 Oct 28.
10
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans.秀丽隐杆线虫中针对奥赛病毒的抗病毒RNA干扰既不是全身性的，也不是跨代的。
J Virol. 2015 Dec;89(23):12035-46. doi: 10.1128/JVI.03664-14. Epub 2015 Sep 23.
Zotero 插件