Inomoto Atsushi, Fukuda Rika, Deguchi Junko, Toyonaga Toshihiro
Faculty of Rehabilitation, Kyushu Nutrition Welfare University: 1-5-1 Kuzuharatakamatsu, Kokuraminami-ku, Kitakyushu-shi, Fukuoka 811-0298, Japan.
Kyushu Rosai Hospital Research Center for the Promotion of Health and Employment Support, Japan.
J Phys Ther Sci. 2017 Sep;29(9):1664-1669. doi: 10.1589/jpts.29.1664. Epub 2017 Sep 15.
[Purpose] Current studies report that patients with chronic obstructive pulmonary disease (COPD) may also have arteriosclerosis. This study aimed to investigate the relationship between respiratory function and arterial stiffness in healthy workers using the brachial-ankle pulse wave velocity (baPWV). [Subjects and Methods] This study included 104 male Japanese workers without COPD. We collected participant information and measured hemodynamics, body composition, and respiratory function. [Results] In the correlation analysis, baPWV showed a significant positive correlation with age, smoking index, systolic blood pressure, diastolic blood pressure, and heart rate, and a significant negative correlation with height, fat free mass, lower limb muscle mass, forced vital capacity (FVC), and forced expiratory volume in one second (FEV1). In multiple regression analysis using factors other than baPWV and respiratory function as adjustment variables, both FVC and FEV1 showed a significant negative relationship with baPWV (p=0.009 and p=0.027, respectively). FEV1/FVC was not significantly related to baPWV (p=0.704). [Conclusion] The results of this study indicated that FEV1/FVC and the proportion of FEV1 predicted, which are indicators of airflow limitation, are not predictors of baPWV in workers without airflow limitation. However, since baPWV showed a significant negative relationship with FVC and FEV 1, the reduction in respiratory function that does not cause airflow limitation, such as FVC or FEV1 decline, may be related to an increase in the risk of arterial stiffness.
[目的]目前的研究报告称，慢性阻塞性肺疾病（COPD）患者可能也存在动脉硬化。本研究旨在利用臂踝脉搏波速度（baPWV）调查健康工作者的呼吸功能与动脉僵硬度之间的关系。[对象与方法]本研究纳入了104名无COPD的日本男性工作者。我们收集了参与者的信息，并测量了血流动力学、身体成分和呼吸功能。[结果]在相关性分析中，baPWV与年龄、吸烟指数、收缩压、舒张压和心率呈显著正相关，与身高、去脂体重、下肢肌肉量、用力肺活量（FVC）和一秒用力呼气容积（FEV1）呈显著负相关。在以baPWV和呼吸功能以外的因素作为调整变量的多元回归分析中，FVC和FEV1均与baPWV呈显著负相关（分别为p = 0.009和p = 0.027）。FEV1/FVC与baPWV无显著相关性（p = 0.704）。[结论]本研究结果表明，气流受限指标FEV1/FVC和预测的FEV1比例在无气流受限的工作者中并非baPWV的预测指标。然而，由于baPWV与FVC和FEV1呈显著负相关，未导致气流受限的呼吸功能降低，如FVC或FEV1下降，可能与动脉僵硬度风险增加有关。
