哮喘和慢性阻塞性肺疾病中的系统性和局部炎症：是否存在关联？

Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

机构信息

NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

出版信息

Proc Am Thorac Soc. 2009 Dec;6(8):638-47. doi: 10.1513/pats.200907-073DP.

DOI:10.1513/pats.200907-073DP

PMID:20008867

Abstract

Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) and probably asthma are associated with low-grade systemic inflammatory changes. In patients with COPD, systemic inflammation is considered a key factor in the pathogenesis of the multicomponent disease manifestations. Spillover of inflammatory mediators into the circulation is generally considered to be the source of this systemic inflammation. Despite this attractive hypothesis, the nature of systemic inflammation in COPD and asthma remains unclear. Available scientific data challenge the spill-over hypothesis. Interventions with biologicals such as TNF-alpha do not modify local or systemic inflammation in these inflammatory respiratory diseases. Adipose tissue-mediated inflammation is discussed as a connecting link of systemic inflammation in asthma and COPD.

摘要

越来越多的证据表明，慢性阻塞性肺疾病（COPD）和可能的哮喘与低度全身炎症变化有关。在 COPD 患者中，全身炎症被认为是多种疾病表现发病机制的关键因素。炎症介质向循环系统的溢出通常被认为是这种全身炎症的来源。尽管这一假设很有吸引力，但 COPD 和哮喘的全身炎症性质仍不清楚。现有科学数据对溢出假说提出了挑战。使用 TNF-α 等生物制剂进行干预并不能改变这些炎症性呼吸系统疾病的局部或全身炎症。脂肪组织介导的炎症被认为是哮喘和 COPD 全身炎症的连接环节。