Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.
Mediators Inflamm. 2017;2017:9538451. doi: 10.1155/2017/9538451. Epub 2017 Aug 28.
The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis.
55 psoriatic patients were enrolled, including 21 men and 34 women, aged from 18 to 88 years. The PASI and body surface area were calculated for all patients. Blood samples were taken to evaluate serum concentration of YKL-40, as well as other inflammatory parameters, including CRP, ESR, white blood cell count, and neutrophil count. The measurements of YKL-40 level were performed by enzyme-linked immunosorbent assay (ELISA).
YKL-40 serum concentration was significantly higher in psoriatic patients than in the control group. No correlations were found between YKL-40 levels and other clinical or laboratory parameters. Serum YKL-40 level was elevated in 81.8% patients, whereas CRP and WBC in 20% and 7.3% of patients, respectively.
YKL-40 could be considered as a useful biomarker of inflammation in psoriasis and is more sensitive than CRP or WBC. Increased YKL-40 may indicate psoriatic patients with a higher level of systemic inflammation, which may determine disease management.
评估银屑病的新炎症生物标志物可以辅助确定治疗决策。几丁质酶 3 样蛋白 1（YKL-40）在炎症中发挥作用。本研究旨在检查 YKL-40 是否是银屑病炎症的可靠生物标志物。
共纳入 55 例银屑病患者，包括 21 名男性和 34 名女性，年龄 18-88 岁。所有患者均计算 PASI 和体表面积。采集血样以评估血清 YKL-40 浓度以及其他炎症参数，包括 CRP、ESR、白细胞计数和中性粒细胞计数。采用酶联免疫吸附试验（ELISA）检测 YKL-40 水平。
银屑病患者的血清 YKL-40 浓度明显高于对照组。YKL-40 水平与其他临床或实验室参数之间无相关性。81.8%的患者血清 YKL-40 水平升高，而 CRP 和 WBC 分别在 20%和 7.3%的患者中升高。
YKL-40 可作为银屑病炎症的有用生物标志物，比 CRP 或 WBC 更敏感。YKL-40 增加可能表明银屑病患者存在更高水平的全身炎症，这可能会影响疾病的管理。
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