Masuda Koji, Tanaka Yoshihiro, Kanehisa Masayuki, Ninomiya Taiga, Inoue Ayako, Higuma Haruka, Kawashima Chiwa, Nakanishi Mari, Okamoto Kana, Akiyoshi Jotaro
Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita, Japan.
Neuropsychiatr Dis Treat. 2017 Sep 8;13:2357-2362. doi: 10.2147/NDT.S138289. eCollection 2017.
In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis.
Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests. Before and after administration of natural reduced or distilled water, we performed blood and urine analyses.
Natural reduced water exhibited anxiolytic-like effects in the conditioned fear and elevated plus maze tests. The mean levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the natural reduced water were significantly lower than the distilled water group. Natural reduced water group also showed decrease in blood-urea nitrogen levels compared with the distilled water group.
These results indicate that natural reduced water may decrease anxiety-related behaviors and prevent heightened oxidative stress.
在日本，已经对诸如富氢电解还原水和天然还原水（如日本水素水）等还原水的效果进行了研究。本研究的目的是确定天然还原水在焦虑和血液生化分析中的作用。
将天然还原水和蒸馏水连续180天给予大鼠，并通过高架十字迷宫、明暗箱、强迫游泳和条件性恐惧试验来检测其对焦虑样行为和抑郁的影响。在给予天然还原水或蒸馏水之前和之后，我们进行了血液和尿液分析。
天然还原水在条件性恐惧和高架十字迷宫试验中表现出抗焦虑样作用。天然还原水组尿中8-羟基-2'-脱氧鸟苷（8-OHdG）的平均水平显著低于蒸馏水组。与蒸馏水组相比，天然还原水组的血尿素氮水平也有所降低。
这些结果表明，天然还原水可能会减少与焦虑相关的行为并预防氧化应激加剧。
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