圆锥角膜的病理生理学：我们如今了解到了什么。
Pathophysiology of Keratoconus: What Do We Know Today.
作者信息
Soiberman Uri, Foster James W, Jun Albert S, Chakravarti Shukti
机构信息
Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, USA.
出版信息
Open Ophthalmol J. 2017 Jul 31;11:252-261. doi: 10.2174/1874364101711010252. eCollection 2017.
Abstract
Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.
摘要
圆锥角膜是一种常见的角膜扩张症，可导致进行性视力损害。大量研究表明圆锥角膜中存在异常的蛋白质表达模式。然而，导致这种疾病的具体机制仍不明确。本综述旨在提供圆锥角膜形态学研究的最新进展，将这些早期研究与蛋白质组学、生物化学和细胞培养研究的当前发现联系起来，并推测可能的致病途径。
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Overview of the Cornea: Structure, Function, and Development.角膜概述：结构、功能与发育
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