Zebhi Banafsheh, Lazkani Mohamad, Bark David
Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Medical Center of the Rockies, University of Colorado Health, Loveland, CO, United States.
Front Cardiovasc Med. 2021 Sep 17;8:734175. doi: 10.3389/fcvm.2021.734175. eCollection 2021.
Calcific aortic stenosis is a progressive disease that has become more prevalent in recent decades. Despite advances in research to uncover underlying biomechanisms, and development of new generations of prosthetic valves and replacement techniques, management of calcific aortic stenosis still comes with unresolved complications. In this review, we highlight underlying molecular mechanisms of acquired aortic stenosis calcification in relation to hemodynamics, complications related to the disease, diagnostic methods, and evolving treatment practices for calcific aortic stenosis.
钙化性主动脉瓣狭窄是一种进行性疾病，在近几十年来变得更加普遍。尽管在揭示潜在生物力学机制的研究以及新一代人工瓣膜和置换技术的开发方面取得了进展，但钙化性主动脉瓣狭窄的管理仍存在未解决的并发症。在本综述中，我们重点介绍了获得性主动脉瓣狭窄钙化与血流动力学相关的潜在分子机制、与该疾病相关的并发症、诊断方法以及钙化性主动脉瓣狭窄不断发展的治疗实践。
