Peghini M, Barabe P, Eynard J P, Morcillo R, Diallo A, Gueye P M
Service de gastroentérologie, Hôpital principal Dakar Sénégal.
Med Trop (Mars). 1987 Oct-Dec;47(4):385-7.
The authors report on two cases of pseudomembranous colitis (P.M.C.) developed in two Senegalese women of 38 and 36 years, and discovered at the 4th and 5th day respectively of an antibiotherapy based on ampicillin. In these two observations, cysts of Entamoeba histolytica histolytica were found in both feces and biopsies. They recall the circumstances of the occurrence, diagnosis techniques and treatment. They underline the unfrequency of this disease in Africa south of Sahara and they discuss the correlation with amoebiasis colitis. One has to keep in mind the possibility of a P.M.C. during any antibiotherapy, and consequently to have a rectoscopy to perform. Such an exploration is enough to pose a diagnosis. In day to day practice it is not necessary to show clearly the specific germ Clostridium difficile or its entero-toxin. To stop any antibiotherapy is required and beneficial. Metronidazole or Vancomycin are the best drugs in this case.
作者报告了两例伪膜性结肠炎（P.M.C.）病例，分别发生在两名38岁和36岁的塞内加尔女性身上，分别在基于氨苄青霉素的抗生素治疗的第4天和第5天被发现。在这两个病例中，在粪便和活检中均发现了溶组织内阿米巴组织型包囊。他们回顾了发病情况、诊断技术和治疗方法。他们强调了这种疾病在撒哈拉以南非洲地区的罕见性，并讨论了与阿米巴性结肠炎的相关性。必须记住在任何抗生素治疗期间都有可能发生P.M.C.，因此需要进行直肠镜检查。这样的检查足以做出诊断。在日常实践中，不必明确显示特定的病原体艰难梭菌或其肠毒素。停止任何抗生素治疗是必要且有益的。在这种情况下，甲硝唑或万古霉素是最佳药物。
