神经系统疾病中的畏光现象。
Photophobia in neurologic disorders.
作者信息
Wu Yiwen, Hallett Mark
机构信息
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1428, Building 10, Room 7D37, Bethesda, MD 20892 USA.
出版信息
Transl Neurodegener. 2017 Sep 20;6:26. doi: 10.1186/s40035-017-0095-3. eCollection 2017.
Abstract
Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestations of photophobia in neurological disorders, including primary headache, blepharospasm, progressive supranuclear palsy, and traumatic brain injury, discuss the definition, etiology and pathogenesis, and summarize practical methods of diagnosis and treatment.
摘要
畏光是许多神经系统疾病中常见的症状，然而，其病理生理学仍不清楚。甚至这个术语也不明确。在本文中，我们回顾了神经系统疾病中畏光的流行病学和临床表现，包括原发性头痛、眼睑痉挛、进行性核上性麻痹和创伤性脑损伤，讨论了定义、病因和发病机制，并总结了实际的诊断和治疗方法。
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本文引用的文献
1
Clinical implications of the melanopsin-based non-image-forming visual system.基于黑视蛋白的非成像视觉系统的临床意义。
Neurology. 2017 Mar 28;88(13):1282-1290. doi: 10.1212/WNL.0000000000003761. Epub 2017 Mar 1.
2
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Surv Ophthalmol. 2016 Jul-Aug;61(4):466-77. doi: 10.1016/j.survophthal.2016.02.001. Epub 2016 Feb 12.
3
Characterization of Migraineurs Having Allodynia: Results of a Large Population-based Study.患有痛觉过敏的偏头痛患者的特征：一项基于大规模人群研究的结果。
Clin J Pain. 2016 Jul;32(7):631-5. doi: 10.1097/AJP.0000000000000301.
4
Photophobia in primary headaches.原发性头痛中的畏光现象。
Headache. 2015 Apr;55(4):600-4. doi: 10.1111/head.12532. Epub 2015 Mar 19.
5
Onabotulinum toxin a for the treatment of headache in service members with a history of mild traumatic brain injury: a cohort study.用于治疗有轻度创伤性脑损伤病史的军人头痛的A型肉毒毒素：一项队列研究。
Headache. 2015 Mar;55(3):395-406. doi: 10.1111/head.12495. Epub 2015 Feb 3.
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7
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