Laake K, Seljeflot I, Schmidt E B, Myhre P, Tveit A, Norseth J, Arnesen H, Solheim S
Oslo University Hospital, Ullevål, Norway.
Faculty of Medicine, University of Oslo, Norway.
JRSM Cardiovasc Dis. 2017 Sep 12;6:2048004017729984. doi: 10.1177/2048004017729984. eCollection 2017 Jan-Dec.
Marine polyunsaturated n-3 fatty acids (n-3 PUFA) may have cardioprotective effects and beneficial influence on the fibrotic process. We evaluated the associations between serum marine n-3 PUFA and selected biomarkers of fibrosis and cardiac remodeling in elderly patients with acute myocardial infarction.
From the ongoing OMega-3 fatty acids in Elderly patients with Myocardial Infarction (OMEMI) trial, 299 patients were investigated. Soluble ST2 (sST2), Galectin-3 (Gal-3) and the serum content of major marine n-3 and n-6 PUFA were analyzed 2-8 weeks after the index acute myocardial infarction.
Gal-3 was inversely correlated to eicosapentaenoic acid (r = -.120, = .039) and docosahexaenoic acid (r = -.125, = .031) and positively correlated to the n-6/n-3 ratio (r = .131, = .023). Gal-3 levels were significantly higher in diabetics vs non-diabetics (12.00 vs 9.61 ng/mL, = .007) and in patients with NYHA class ≥III for dyspnea at inclusion (11.33 vs 9.75 ng/mL, = .006).
The associations between the marine n-3 PUFA and levels of Gal-3 indicate beneficial effects of n-3 PUFA on cardiac remodeling in an elderly population with acute myocardial infarction.
海洋多不饱和n-3脂肪酸（n-3 PUFA）可能具有心脏保护作用，并对纤维化过程产生有益影响。我们评估了老年急性心肌梗死患者血清海洋n-3 PUFA与选定的纤维化和心脏重塑生物标志物之间的关联。
在正在进行的老年心肌梗死患者的欧米伽-3脂肪酸（OMEMI）试验中，对299例患者进行了研究。在首次急性心肌梗死后2-8周分析可溶性ST2（sST2）、半乳糖凝集素-3（Gal-3）以及主要海洋n-3和n-6 PUFA的血清含量。
Gal-3与二十碳五烯酸呈负相关（r = -0.120，P = 0.039），与二十二碳六烯酸呈负相关（r = -0.125，P = 0.031），与n-6/n-3比值呈正相关（r = 0.131，P = 0.023）。糖尿病患者的Gal-3水平显著高于非糖尿病患者（12.00对9.61 ng/mL，P = 0.007），纳入时纽约心脏协会（NYHA）心功能分级≥III级的呼吸困难患者的Gal-3水平也显著高于其他患者（11.33对9.75 ng/mL，P = = 0. = 006）。
海洋n-3 PUFA与Gal-3水平之间的关联表明，n-3 PUFA对老年急性心肌梗死人群的心脏重塑具有有益作用。
