Nakamura S, Nakamura S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Neurobiol Aging. 1987 Nov-Dec;8(6):578-9. doi: 10.1016/0197-4580(87)90143-6.
Qualitative changes in normal aging and Alzheimer's disease (AD) are as important as quantitative changes. Although qualitative changes do not c-vary with quantitative differences in every respect, quantitative changes, nevertheless, often accurately reflect qualitative changes. Moreover, the complementary use of each provides a more detailed characterization of brain changes with aging and AD. The quantitative and qualitative changes of choline acetyltransferase, as well as somatostatin-containing neurons and dendrites, in human cortex are described as examples of this.
正常衰老和阿尔茨海默病（AD）中的质性变化与量性变化同样重要。尽管质性变化在各方面并非都与量性差异共变，但量性变化常常能准确反映质性变化。此外，两者的互补运用能更详细地描述衰老及AD过程中大脑的变化。本文以人类皮质中胆碱乙酰转移酶、含生长抑素的神经元及树突的量性和质性变化为例进行说明。
