Brizzee K R
Tulane University, Delta Primate Research Center, Covington, LA 70433.
Neurobiol Aging. 1987 Nov-Dec;8(6):579-80. doi: 10.1016/0197-4580(87)90144-8.
Evidence is reviewed regarding neuron numbers and dendritic extent in normal aging in rodent, monkey and human brain and in Alzheimer's disease (AD) in man. Neuron loss and change in dendritic extent appear to be regionally specific but not identical in rodents and primates. In AD there is excess neuron loss and dendritic regression in some but not all brain regions. Overlap between AD and control groups, however, is known to occur. Methods to assess dynamic morphology of the living brain may be superior to analysis of static, post-mortem brain structure in explaining functional deficits in AD and normal aging.
本文综述了关于啮齿动物、猴子和人类大脑正常衰老过程以及人类阿尔茨海默病（AD）中神经元数量和树突范围的证据。神经元丢失和树突范围的变化似乎具有区域特异性，但在啮齿动物和灵长类动物中并不相同。在AD中，部分而非所有脑区存在过量的神经元丢失和树突退化。然而，已知AD组和对照组之间存在重叠。在解释AD和正常衰老中的功能缺陷方面，评估活体大脑动态形态的方法可能优于对死后静态脑结构的分析。
