Chen Dan, Liu Ding, Chen Zhiwei
Department of Orthopedics, The First Affiliated Hospital of University of South China, Hengyang, P.R. China.
Tumour Biol. 2017 Sep;39(9):1010428317705762. doi: 10.1177/1010428317705762.
Osteosarcoma is the most common primary bone cancer in young adults and adolescents. Drug resistance is the main cause leading to therapeutical failure. The mechanisms of drug resistance of osteosarcoma have not been fully understood. Notably, recent researches associate microRNA with drug resistance in osteosarcoma cells, raising the awareness that targeting microRNAs may help in chemotherapy success. In this review, we summarize the mechanisms linking microRNAs to drug resistance and ongoing researches on microRNAs in drug response to osteosarcoma. In addition, the therapeutic potential of microRNAs in chemotherapy will also be discussed.
骨肉瘤是年轻成年人和青少年中最常见的原发性骨癌。耐药性是导致治疗失败的主要原因。骨肉瘤的耐药机制尚未完全明确。值得注意的是，最近的研究将微小RNA与骨肉瘤细胞的耐药性联系起来，这使人们意识到靶向微小RNA可能有助于化疗取得成功。在本综述中，我们总结了将微小RNA与耐药性联系起来的机制以及目前关于微小RNA在骨肉瘤药物反应方面的研究。此外，还将讨论微小RNA在化疗中的治疗潜力。
