Bansode Rishipal R, Khatiwada Janak R, Losso Jack N, Williams Leonard L
Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, North Carolina Agricultural and Technical State University, Kannapolis, NC 28081, USA.
School of Nutrition & Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Diseases. 2016 Apr 28;4(2):21. doi: 10.3390/diseases4020021.
Proanthocyanidins are oligomeric flavonoids found in plant sources, most notably in apples, cinnamon, grape skin and cocoa beans. They have been also found in substantial amounts in cranberry, black currant, green tea, black tea and peanut skins. These compounds have been recently investigated for their health benefits. Proanthocyanidins have been demonstrated to have positive effects on various metabolic disorders such as inflammation, obesity, diabetes and insulin resistance. Another upcoming area of research that has gained widespread interest is microRNA (miRNA)-based anticancer therapies. MicroRNAs are short non-coding RNA segments, which plays a crucial role in RNA silencing and post-transcriptional regulation of gene expression. Currently, miRNA based anticancer therapies are being investigated either alone or in combination with current treatment methods. In this review, we summarize the current knowledge and investigate the potential of naturally occurring proanthocyanidins in modulating miRNA expression. We will also assess the strategies and challenges of using this approach as potential cancer therapeutics.
原花青素是一种存在于植物中的低聚黄酮类化合物，最显著的来源包括苹果、肉桂、葡萄皮和可可豆。在蔓越莓、黑加仑、绿茶、红茶和花生皮中也发现了大量的原花青素。近年来，人们对这些化合物的健康益处进行了研究。已证明原花青素对各种代谢紊乱，如炎症、肥胖、糖尿病和胰岛素抵抗具有积极作用。另一个引起广泛关注的新兴研究领域是基于微小RNA（miRNA）的抗癌疗法。微小RNA是短的非编码RNA片段，在RNA沉默和基因表达的转录后调控中起关键作用。目前，基于miRNA的抗癌疗法正在单独或与现有治疗方法联合进行研究。在这篇综述中，我们总结了当前的知识，并研究了天然存在的原花青素在调节miRNA表达方面的潜力。我们还将评估将这种方法用作潜在癌症治疗手段的策略和挑战。
