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可可多酚的心血管效应——综述

The Cardiovascular Effects of Cocoa Polyphenols-An Overview.

作者信息

Aprotosoaie Ana Clara, Miron Anca, Trifan Adriana, Luca Vlad Simon, Costache Irina-Iuliana

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa Iasi, Universitatii Str. 16, 700115 Iasi, Romania.

Department of Cardiology, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa Iasi, Universitatii Str. 16, 700115 Iasi, Romania.

出版信息

Diseases. 2016 Dec 17;4(4):39. doi: 10.3390/diseases4040039.

DOI:10.3390/diseases4040039
PMID:28933419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456324/
Abstract

Cocoa is a rich source of high-quality antioxidant polyphenols. They comprise mainly catechins (29%-38% of total polyphenols), anthocyanins (4% of total polyphenols) and proanthocyanidins (58%-65% of total polyphenols). A growing body of experimental and epidemiological evidence highlights that the intake of cocoa polyphenols may reduce the risk of cardiovascular events. Beyond antioxidant properties, cocoa polyphenols exert blood pressure lowering activity, antiplatelet, anti-inflammatory, metabolic and anti-atherosclerotic effects, and also improve endothelial function. This paper reviews the role of cocoa polyphenols in cardiovascular protection, with a special focus on mechanisms of action, clinical relevance and correlation between antioxidant activity and cardiovascular health.

摘要

可可富含优质抗氧化多酚。它们主要包括儿茶素（占总多酚的29%-38%）、花青素（占总多酚的4%）和原花青素（占总多酚的58%-65%）。越来越多的实验和流行病学证据表明，摄入可可多酚可能降低心血管事件的风险。除了抗氧化特性外，可可多酚还具有降血压活性、抗血小板、抗炎、代谢和抗动脉粥样硬化作用，还能改善内皮功能。本文综述了可可多酚在心血管保护中的作用，特别关注其作用机制、临床相关性以及抗氧化活性与心血管健康之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0c06d88c8600/diseases-04-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0e01cf19aa92/diseases-04-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/d0c5489abbf3/diseases-04-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/d0909158c930/diseases-04-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0bec9d32624a/diseases-04-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0c06d88c8600/diseases-04-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0e01cf19aa92/diseases-04-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/d0c5489abbf3/diseases-04-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/d0909158c930/diseases-04-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0bec9d32624a/diseases-04-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e59/5456324/0c06d88c8600/diseases-04-00039-g005.jpg

相似文献

[1]
The Cardiovascular Effects of Cocoa Polyphenols-An Overview.

Diseases. 2016-12-17

[2]
Cocoa, blood pressure, and cardiovascular health.

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[3]
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[4]
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[5]
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[6]
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J Agric Food Chem. 2009-10-14

[7]
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Curr Med Chem. 2018

[8]
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Nutrients. 2020-11-30

[9]
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Nutrients. 2023-5-13

[10]
Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies.

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[1]
Exploring the antimicrobial activity of fermented and non-fermented cocoa bean shell extracts through metabolomics analysis and synergistic studies.

J Sci Food Agric. 2025-9

[2]
The role of cocoa flavanols in modulating peripheral and cerebral microvascular function in healthy individuals and populations at-risk of cardiovascular disease: a systematic review.

Nutr J. 2025-4-11

[3]
Activation of Human Adrenergic Receptors and Trace Amine-Associated Receptor 1 by Phenethylamine Analogues Present in Food Supplements.

Nutrients. 2024-5-22

[4]
Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects.

Curr Res Food Sci. 2024-4-20

[5]
Cardiometabolic Risk: Characteristics of the Intestinal Microbiome and the Role of Polyphenols.

Int J Mol Sci. 2023-9-6

[6]
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Nutr Res Pract. 2023-4

[7]
Effects of Ozone Application on Microbiological Stability and Content of Sugars and Bioactive Compounds in the Fruit of the Saskatoon Berry ( Nutt.).

Molecules. 2022-9-30

[8]
Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension.

Nutrients. 2022-6-28

[9]
Quercetin prevents insulin dysfunction in hypertensive animals.

J Diabetes Metab Disord. 2022-2-28

[10]
Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial.

Nutrients. 2022-4-29

本文引用的文献

[1]
Flavor Chemistry of Cocoa and Cocoa Products-An Overview.

Compr Rev Food Sci Food Saf. 2016-1

[2]
Cocoa flavanols reduce N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure.

ESC Heart Fail. 2016-6

[3]
A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.

Int J Cardiol. 2016-11-15

[4]
Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study.

Mol Nutr Food Res. 2016-11

[5]
Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans.

Nutrients. 2016-4-9

[6]
Antioxidant and antiplatelet activity by polyphenol-rich nutrients: focus on extra virgin olive oil and cocoa.

Br J Clin Pharmacol. 2017-1

[7]
Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double-Blind, Randomized, Placebo-Controlled Trial.

Clin J Am Soc Nephrol. 2016-1-7

[8]
Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial.

Am J Clin Nutr. 2015-11-4

[9]
Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study.

Br J Nutr. 2015-10-28

[10]
Acute Cocoa Supplementation Increases Postprandial HDL Cholesterol and Insulin in Obese Adults with Type 2 Diabetes after Consumption of a High-Fat Breakfast.

J Nutr. 2015-10

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