Department of Rehabilitation Sciences, Ghent University, 9000 Ghent, Belgium.
Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369-URePSSS-Unité de Recherche Pluridisciplinaire Sport Santé Société, F-59000 Lille, France.
Nutrients. 2022 Jun 28;14(13):2692. doi: 10.3390/nu14132692.
Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects have only been scarcely studied in T2DM. Therefore, we performed a study to assess the effects on vascular reactivity of a single dose of CF (790 mg) in T2DM and whether certain antihypertensive drugs may modulate these effects.
24 non-diabetic and 11 T2DM subjects were studied in a cross-over design. Fasting blood samples, blood pressure (BP), and arterial vasoreactivity (flow-mediated dilation) were assessed before and 70 min after capsule ingestion. Muscle microvascular reactivity was only assessed after capsule ingestion. Age, waist-to-hip ratio, BP at baseline, and the use of antihypertensive drugs were regarded as covariates in a mixed models analysis.
CF ingestion did not affect any parameter. However, independent of the type of capsules ingested, a decrease in diastolic BP by 3 mmHg (95% CI: -4.0; -2.0) and an increase in the change in brachial artery diameter (pre vs. post occlusion) by 0.06 mm (95% CI: 0.01; 0.12) were detected in the non-diabetic group, while they remained unchanged in the T2DM group.
No beneficial effects of CF were detected on vascular reactivity parameters in T2DM and non-diabetic participants.
2 型糖尿病（T2DM）与血管并发症的高风险相关。有趣的是，可可黄烷醇（CF）可以对非糖尿病患者发挥有益的血管作用。然而，这些作用在 T2DM 中研究甚少。因此，我们进行了一项研究，以评估 T2DM 患者单次 CF（790mg）剂量对血管反应性的影响，以及某些降压药物是否可能调节这些作用。
24 名非糖尿病患者和 11 名 T2DM 患者以交叉设计进行研究。空腹血样、血压（BP）和动脉血管反应性（血流介导的扩张）在胶囊摄入前后 70 分钟进行评估。仅在胶囊摄入后评估肌肉微血管反应性。在混合模型分析中，将年龄、腰臀比、基线 BP 和使用降压药物视为协变量。
CF 摄入不影响任何参数。然而，与摄入的胶囊类型无关，在非糖尿病组中，舒张压降低 3mmHg（95%CI：-4.0；-2.0），肱动脉直径变化（闭塞前与闭塞后）增加 0.06mm（95%CI：0.01；0.12），而 T2DM 组无变化。
在 T2DM 和非糖尿病参与者中，CF 对血管反应性参数没有有益影响。
